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ORP2A OSBP(oxysterol binding protein)-related protein 2A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828349, updated on 18-Sep-2024

Summary

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Official Symbol
ORP2A
Official Full Name
OSBP(oxysterol binding protein)-related protein 2A
Primary source
TAIR:AT4G22540
Locus tag
AT4G22540
See related
Araport:AT4G22540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F7K2.120; F7K2_120; OSBP(oxysterol binding protein)-related protein 2A
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Genomic context

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See ORP2A in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Sequence:
Chromosome: 4; NC_003075.7 (11860409..11866475, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene miscRNA Neighboring gene Phosphatidic acid phosphatase (PAP2) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation. Yu Q, et al. Plant Physiol, 2023 Aug 3. PMID 37073508
  2. Screening for in planta protein-protein interactions combining bimolecular fluorescence complementation with flow cytometry. Berendzen KW, et al. Plant Methods, 2012 Jul 12. PMID 22789293, Free PMC Article
  3. Learning the lipid language of plant signalling. van Leeuwen W, et al. Trends Plant Sci, 2004 Aug. PMID 15358268
  4. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
  5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
    Title: Lipid transport protein ORP2A promotes glucose signaling by facilitating RGS1 degradation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001036621.3
NM_001203871.1
NM_001341552.1
NM_001341553.1
NM_118380.3
NM_202863.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
OSBP(oxysterol binding protein)-related protein 2A
NP_001031698.1
  • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001190800.1
  • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1).
NP_567662.1
  • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Oxysterol-binding protein (InterPro:IPR000648), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_974592.1
  • OSBP(oxysterol binding protein)-related protein 2A (ORP2A); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 2B (TAIR:AT4G12460.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    11860409..11866475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118380.3 → NP_567662.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567662.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WMK9, Q56W69, Q940Y1, Q9SUW5
    UniProtKB/TrEMBL
    A0A178UYT2, A0A5S9XUT6
    Conserved Domains (2) summary
    cd13294
    Location:53 → 185
    PH_ORP_plant; Plant Oxysterol binding protein related protein Pleckstrin homology (PH) domain
    pfam01237
    Location:344 → 696
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_001341552.1 → NP_001328217.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WMK9, Q56W69, Q940Y1, Q9SUW5
    UniProtKB/TrEMBL
    A0A178UYT2, A0A5S9XUT6
    Conserved Domains (2) summary
    cd13294
    Location:53 → 185
    PH_ORP_plant; Plant Oxysterol binding protein related protein Pleckstrin homology (PH) domain
    pfam01237
    Location:344 → 696
    Oxysterol_BP; Oxysterol-binding protein

  3. NM_001341553.1 → NP_001328218.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F570
    Conserved Domains (1) summary
    pfam01237
    Location:133 → 485
    Oxysterol_BP; Oxysterol-binding protein

  4. NM_001203871.1 → NP_001190800.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190800.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F570
    Conserved Domains (1) summary
    pfam01237
    Location:133 → 485
    Oxysterol_BP; Oxysterol-binding protein

  5. NM_202863.3 → NP_974592.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974592.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F570
    Conserved Domains (1) summary
    pfam01237
    Location:133 → 485
    Oxysterol_BP; Oxysterol-binding protein

  6. NM_001036621.3 → NP_001031698.1  OSBP(oxysterol binding protein)-related protein 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F570
    Conserved Domains (1) summary
    pfam01237
    Location:133 → 485
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q940Y1.1

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