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ENDO5 endonuclease 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828246, updated on 18-Sep-2024

Summary

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Official Symbol
ENDO5
Official Full Name
endonuclease 5
Primary source
TAIR:AT4G21600
Locus tag
AT4G21600
See related
Araport:AT4G21600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
endonuclease 5; F17L22.60
Summary
Encodes a protein with mismatch-specific endonuclease activity with a preference for T/G, A/G, and G/G of single base mismatches. It also has the ability to cleave indel types of mismatches (heteroduplexes with loops).
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Genomic context

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See ENDO5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (11484981..11487535)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene endonuclease 3 Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene lsd one like 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities. Lesniewicz K, et al. Plant Cell Physiol, 2013 Jul. PMID 23620482
  2. Characterization of Arabidopsis thaliana mismatch specific endonucleases: application to mutation discovery by TILLING in pea. Triques K, et al. Plant J, 2007 Sep. PMID 17651368
  3. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
  4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that five S1-like nucleases have been named as ENDO1 (BFN1, AT1G11190), ENDO2 (AT1G68290), ENDO3 (AT4G21590), ENDO4 (AT4G21585) and ENDO5 (AT4G21600).
    Title: The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities.
  2. ENDO5 is a root specific, Zn2+-dependent nuclease which degrades ssDNA and RNA at neutral pH
    Title: The plant s1-like nuclease family has evolved a highly diverse range of catalytic capabilities.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_118280.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables T/G mismatch-specific endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
endonuclease 5
NP_567631.1
  • endonuclease 5 (ENDO5); FUNCTIONS IN: T/G mismatch-specific endonuclease activity, single-stranded DNA specific endodeoxyribonuclease activity, endonuclease activity, nucleic acid binding; INVOLVED IN: DNA catabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Phospholipase C/P1 nuclease, core (InterPro:IPR008947), S1/P1 nuclease (InterPro:IPR003154); BEST Arabidopsis thaliana protein match is: endonuclease 4 (TAIR:AT4G21585.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    11484981..11487535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118280.2 → NP_567631.1  endonuclease 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JJL3, O65425, Q8LA68
    UniProtKB/TrEMBL
    A0A5S9XV62, A0A654FRK8
    Conserved Domains (1) summary
    pfam02265
    Location:21 → 288
    S1-P1_nuclease; S1/P1 Nuclease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4JJL3.1

Gene LinkOut

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