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PMS1 DNA mismatch repair protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827997, updated on 18-Sep-2024

Summary

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Official Symbol
PMS1
Official Full Name
DNA mismatch repair protein
Primary source
TAIR:AT4G02460
Locus tag
AT4G02460
See related
Araport:AT4G02460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtPMS1; ATPMS1; POSTMEIOTIC SEGREGATION 1; T14P8.6; T14P8_6
Summary
Encodes a protein similar to PMS1 in yeast, a member of the family of eukaryotic MutL homologs. The protein appears to play a role in DNA mismatch repair and in the suppression of somatic homeologous recombination.
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Genomic context

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See PMS1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Sequence:
Chromosome: 4; NC_003075.7 (1076090..1080727, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene HSP20-like chaperones superfamily protein Neighboring gene F-box family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene AAA-type ATPase family protein Neighboring gene translocase of chloroplast-like protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast mutator phenotype enforced by Arabidopsis PMS1 expression. Galles C, et al. Mol Biol Rep, 2013 Mar. PMID 23184005
  2. PMS1 from Arabidopsis thaliana: optimization of protein overexpression in Escherichia coli. Galles C, et al. Mol Biol Rep, 2011 Feb. PMID 20571910
  3. The Arabidopsis DNA mismatch repair gene PMS1 restricts somatic recombination between homeologous sequences. Li L, et al. Plant Mol Biol, 2009 Apr. PMID 19115045
  4. Involvement of the Arabidopsis thaliana AtPMS1 gene in somatic repeat instability. Alou AH, et al. Plant Mol Biol, 2004 Oct. PMID 15604748
  5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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NM_001340378.1
NM_001340379.1
NM_001340380.1
NM_116479.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fruit development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seed development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mismatch repair complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNA mismatch repair protein
NP_567236.1
  • POSTMEIOTIC SEGREGATION 1 (PMS1); FUNCTIONS IN: mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, fruit development, seed development, DNA recombination, pollen development; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA mismatch repair protein, C-terminal (InterPro:IPR013507), MutL, C-terminal, dimerisation (InterPro:IPR014790), DNA mismatch repair protein, N-terminal (InterPro:IPR014763), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA mismatch repair protein (InterPro:IPR002099), Post Meiotic Segregation 2 (InterPro:IPR015434), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721); BEST Arabidopsis thaliana protein match is: MUTL-homologue 1 (TAIR:AT4G09140.1); Has 10471 Blast hits to 7086 proteins in 2377 species: Archae - 138; Bacteria - 7516; Metazoa - 568; Fungi - 666; Plants - 148; Viruses - 0; Other Eukaryotes - 1435 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    1076090..1080727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116479.4 → NP_567236.1  DNA mismatch repair protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567236.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81287, Q8GY98, Q941I6
    UniProtKB/TrEMBL
    A0A5S9XP74
    Conserved Domains (4) summary
    smart00853
    Location:707 → 863
    MutL_C; MutL C terminal dimerisation domain
    COG0323
    Location:16 → 895
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
    cd03484
    Location:224 → 349
    MutL_Trans_hPMS_2_like; MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second ...
    cl00075
    Location:37 → 141
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

  2. NM_001340378.1 → NP_001329306.1  DNA mismatch repair protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B7A7, A0A5S9XP74

  3. NM_001340380.1 → NP_001329304.1  DNA mismatch repair protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B7A4, A0A5S9XP74

  4. NM_001340379.1 → NP_001329305.1  DNA mismatch repair protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B7A8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q941I6.1

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