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ZAC Calcium-dependent ARF-type GTPase activating protein family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827864, updated on 18-Sep-2024

Summary

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Official Symbol
ZAC
Official Full Name
Calcium-dependent ARF-type GTPase activating protein family
Primary source
TAIR:AT4G21160
Locus tag
AT4G21160
See related
Araport:AT4G21160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AGD12; ARF-GAP domain 12
Summary
ADP-ribosylation factor GTPase-activating protein containing zinc finger and C2 domains and a novel PI-3-P-binding protein region. Binds PI-3-P. Highest expression levels in flowering tissue, rosettes and roots. A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes.
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Genomic context

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See ZAC in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (11284076..11286767)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene copper ion-binding protein Neighboring gene ribophorin II (RPN2) family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene DnaJ / Sec63 Brl domains-containing protein Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Promiscuous and specific phospholipid binding by domains in ZAC, a membrane-associated Arabidopsis protein with an ARF GAP zinc finger and a C2 domain. Jensen RB, et al. Plant Mol Biol, 2000 Dec. PMID 11202441
  2. EHB1 and AGD12, two calcium-dependent proteins affect gravitropism antagonistically in Arabidopsis thaliana. Dümmer M, et al. J Plant Physiol, 2016 Nov 1. PMID 27728837
  3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
  4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In contrast to agd12 mutants, ehb1 loss-of function seedlings displayed enhanced gravitropic bending.
    Title: EHB1 and AGD12, two calcium-dependent proteins affect gravitropism antagonistically in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_118235.4
NM_179085.3
NM_202852.2
NM_202853.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Calcium-dependent ARF-type GTPase activating protein family
NP_567620.1
  • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_849416.1
  • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 8253 Blast hits to 7394 proteins in 304 species: Archae - 0; Bacteria - 3; Metazoa - 4692; Fungi - 1290; Plants - 1388; Viruses - 0; Other Eukaryotes - 880 (source: NCBI BLink).
NP_974581.1
  • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_974582.1
  • ZAC; FUNCTIONS IN: phospholipid binding, ARF GTPase activator activity; INVOLVED IN: intracellular protein transport; LOCATED IN: Golgi apparatus, plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 13 (TAIR:AT4G05330.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    11284076..11286767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118235.4 → NP_567620.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49557, Q0WNN1, Q8L9H2, Q9FVJ3
    UniProtKB/TrEMBL
    A0A178UUS8, A0A5S9XUC9
    Conserved Domains (2) summary
    cd04038
    Location:180 → 324
    C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
    cd08204
    Location:18 → 124
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

  2. NM_202852.2 → NP_974581.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974581.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49557, Q0WNN1, Q8L9H2, Q9FVJ3
    UniProtKB/TrEMBL
    A0A178UUS8, A0A5S9XUC9
    Conserved Domains (2) summary
    cd04038
    Location:180 → 324
    C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
    cd08204
    Location:18 → 124
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

  3. NM_202853.3 → NP_974582.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49557, Q0WNN1, Q8L9H2, Q9FVJ3
    UniProtKB/TrEMBL
    A0A178UUS8, A0A5S9XUC9
    Conserved Domains (2) summary
    cd04038
    Location:180 → 324
    C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
    cd08204
    Location:18 → 124
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

  4. NM_179085.3 → NP_849416.1  Calcium-dependent ARF-type GTPase activating protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849416.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49557, Q0WNN1, Q8L9H2, Q9FVJ3
    UniProtKB/TrEMBL
    A0A178UUS8, A0A5S9XUC9
    Conserved Domains (2) summary
    cd04038
    Location:180 → 324
    C2_ArfGAP; C2 domain present in Arf GTPase Activating Proteins (GAP)
    cd08204
    Location:18 → 124
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FVJ3.1

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