6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: 6-phosphogluconate dehydrogenase family protein
Primary source: TAIR:AT4G20930
Locus tag: AT4G20930
See related: Araport:AT4G20930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T13K14.90; T13K14_90
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (11198251..11201106, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role in the catabolism of valine and isoleucine but not leucine
Title: 3-Hydroxyisobutyrate Dehydrogenase Is Involved in Both, Valine and Isoleucine Degradation in Arabidopsis thaliana.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_118211.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 3-hydroxyisobutyrate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-hydroxyisobutyrate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-leucine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within valine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: 6-phosphogluconate dehydrogenase family protein

NP_567617.1

6-phosphogluconate dehydrogenase family protein; FUNCTIONS IN: in 7 functions; INVOLVED IN: oxidation reduction, pentose-phosphate shunt, valine metabolic process, valine catabolic process, metabolic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, NAD-binding (InterPro:IPR006115), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), 3-hydroxyacid dehydrogenase/reductase (InterPro:IPR015815), NAD(P)-binding domain (InterPro:IPR016040), 3-hydroxyisobutyrate dehydrogenase (InterPro:IPR011548), 3-hydroxyisobutyrate dehydrogenase-related, conserved site (InterPro:IPR002204); BEST Arabidopsis thaliana protein match is: glyoxylate reductase 2 (TAIR:AT1G17650.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

11198251..11201106 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001341465.1 → NP_001329408.1 6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V4D8, A0A1P8B7M5
NM_118211.5 → NP_567617.1 6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567617.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q1ECP8, Q8LC25, Q9SUC0

UniProtKB/TrEMBL

A0A178V240, A0A5S9XV66

Conserved Domains (3) summary

TIGR01692
Location:42 → 338

HIBADH; 3-hydroxyisobutyrate dehydrogenase

pfam03446
Location:40 → 210

NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase

pfam14833
Location:213 → 340

NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase