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AAH allantoate amidohydrolase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827752, updated on 18-Sep-2024

Summary

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Official Symbol
AAH
Official Full Name
allantoate amidohydrolase
Primary source
TAIR:AT4G20070
Locus tag
AT4G20070
See related
Araport:AT4G20070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
allantoate amidohydrolase; ATAAH; F18F4.170; F18F4_170
Summary
The gene encoding Arabidopsis thaliana Allantoate Amidohydrolase (AtAAH)which catalyzes the allantoate deiminase reaction (EC 3.5.3.9)is expressed in all parts of the plant being consistent with a function in purine turnover in Arabidopsis.
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Genomic context

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See AAH in Genome Data Viewer
Location:
chromosome: 4
Exon count:
12
Sequence:
Chromosome: 4; NC_003075.7 (10861382..10864765)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene ARM repeat superfamily protein Neighboring gene Calcium-dependent lipid-binding (CaLB domain) plant phosphoribosyltransferase family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtAAH encodes a protein with allantoate amidohydrolase activity from Arabidopsis thaliana. Todd CD, et al. Planta, 2006 Apr. PMID 16496096
  2. Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean. Werner AK, et al. Plant Physiol, 2008 Feb. PMID 18065556, Free PMC Article
  3. The ureide-degrading reactions of purine ring catabolism employ three amidohydrolases and one aminohydrolase in Arabidopsis, soybean, and rice. Werner AK, et al. Plant Physiol, 2013 Oct. PMID 23940254, Free PMC Article
  4. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Werner AK, et al. Nat Chem Biol, 2010 Jan. PMID 19935661
  5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The isolation and characterization of Allantoate amidohydrolase in A. thaliana and G. max are reported.
    Title: Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean.
  2. Mutants demonstrated higher allantoate levels than wild-type plants in the presence and absence of exogenous ureides.
    Title: AtAAH encodes a protein with allantoate amidohydrolase activity from Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001341398.1
NM_118126.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables allantoate deiminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables allantoate deiminase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within purine nucleobase catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within purine nucleobase catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ureide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ureide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
allantoate amidohydrolase
NP_193740.1
  • allantoate amidohydrolase (AAH); CONTAINS InterPro DOMAIN/s: Peptidase M20 (InterPro:IPR002933), ArgE/DapE/ACY1/CPG2/YscS, conserved site (InterPro:IPR001261), Amidase, hydantoinase/carbamoylase (InterPro:IPR010158), Peptidase M20, dimerisation (InterPro:IPR011650); BEST Arabidopsis thaliana protein match is: ureidoglycolate amidohydrolase (TAIR:AT5G43600.1); Has 3541 Blast hits to 3529 proteins in 962 species: Archae - 54; Bacteria - 2502; Metazoa - 32; Fungi - 158; Plants - 88; Viruses - 0; Other Eukaryotes - 707 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    10861382..10864765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118126.4 → NP_193740.1  allantoate amidohydrolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193740.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49434
    UniProtKB/TrEMBL
    A0A5S9XU55, A0A654FRH5
    Conserved Domains (1) summary
    cd03884
    Location:97 → 522
    M20_bAS; M20 Peptidase beta-alanine synthase, an amidohydrolase

  2. NM_001341398.1 → NP_001329687.1  allantoate amidohydrolase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B8I1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O49434.2

Gene LinkOut

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