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CYP707A1 cytochrome P450, family 707, subfamily A, polypeptide 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827663, updated on 18-Sep-2024

Summary

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Official Symbol
CYP707A1
Official Full Name
cytochrome P450, family 707, subfamily A, polypeptide 1
Primary source
TAIR:AT4G19230
Locus tag
AT4G19230
See related
Araport:AT4G19230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
''cytochrome P450; cytochrome P450; family 707; polypeptide 1; polypeptide 1''; subfamily A; T18B16.200; T18B16_200
Summary
Encodes a protein with ABA 8'-hydroxylase activity, involved in ABA catabolism. Member of the CYP707A gene family. CYP707A1 appears to play an important role in determining the ABA levels in dry seeds. Gene involved in postgermination growth. Overexpression of CYP707A1 leads to a decrease in ABA levels and a reduction in after-ripening period to break dormancy.
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Genomic context

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See CYP707A1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
7
Sequence:
Chromosome: 4; NC_003075.7 (10521259..10523961)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNAse l inhibitor protein 2 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene miscRNA Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis. Okamoto M, et al. Plant Physiol, 2009 Feb. PMID 19036833, Free PMC Article
  2. CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis. Okamoto M, et al. Plant Physiol, 2006 May. PMID 16543410, Free PMC Article
  3. Hypoxia reshapes Arabidopsis root architecture by integrating ERF-VII factor response and abscisic acid homoeostasis. Eysholdt-Derzsó E, et al. Plant Cell Environ, 2024 Aug. PMID 38616485
  4. Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. Saito S, et al. Plant Physiol, 2004 Apr. PMID 15064374, Free PMC Article
  5. Seed dormancy and ABA metabolism in Arabidopsis and barley: the role of ABA 8'-hydroxylase. Millar AA, et al. Plant J, 2006 Mar. PMID 16507085

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYP707A1 inactivates local abscisic acid pools inside the guard cells of Arabidopsis.
    Title: High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis.
  2. CYP707A1 is expressed in Arabidopsis seeds predominantly during mid-maturation and is down-regulated during late-maturation and plays a distinct role in seed development and postgermination growth.
    Title: CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_118043.2
NM_202845.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables (+)-abscisic acid 8'-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within release of seed from dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to red or far red light IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
cytochrome P450, family 707, subfamily A, polypeptide 1
NP_567581.1
  • ''cytochrome P450, family 707, subfamily A, polypeptide 1'' (CYP707A1); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_974574.1
  • ''cytochrome P450, family 707, subfamily A, polypeptide 1'' (CYP707A1); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    10521259..10523961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118043.2 → NP_567581.1  cytochrome P450, family 707, subfamily A, polypeptide 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567581.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65624, Q949P1
    UniProtKB/TrEMBL
    A0A178V0Q6, A0A5S9XTX9, A0A7G2F3V2
    Conserved Domains (1) summary
    PLN02196
    Location:1 → 463
    PLN02196; abscisic acid 8'-hydroxylase

  2. NM_202845.1 → NP_974574.1  cytochrome P450, family 707, subfamily A, polypeptide 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974574.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F3V2, A8MRX5
    Conserved Domains (1) summary
    PLN02196
    Location:1 → 464
    PLN02196; abscisic acid 8'-hydroxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q949P1.1

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