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TPS5 trehalose phosphatase/synthase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827498, updated on 18-Sep-2024

Summary

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Official Symbol
TPS5
Official Full Name
trehalose phosphatase/synthase 5
Primary source
TAIR:AT4G17770
Locus tag
AT4G17770
See related
Araport:AT4G17770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATTPS5; DL4920W; FCAALL.9; TREHALOSE -6-PHOSPHATASE SYNTHASE S5; trehalose phosphatase/synthase 5
Summary
Encodes an enzyme putatively involved in trehalose biosynthesis. The protein has a trehalose synthase (TPS)-like domain that may or may not be active as well as a trehalose phosphatase (TPP)-like domain. Phosphorylated TPS5 extracted from Arabidopsis cells binds directly to 14-3-3 isoforms.
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Genomic context

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See TPS5 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Sequence:
Chromosome: 4; NC_003075.7 (9876172..9880386)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene PCNA domain-containing protein Neighboring gene tRNA-Trp Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene myb domain protein 39 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trehalose phosphate synthase 5-dependent trehalose metabolism modulates basal defense responses in Arabidopsis thaliana. Wang X, et al. J Integr Plant Biol, 2019 Apr. PMID 30058771
  2. Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose. Harthill JE, et al. Plant J, 2006 Jul. PMID 16771775
  3. The transcriptional co-activator MBF1c is a key regulator of thermotolerance in Arabidopsis thaliana. Suzuki N, et al. J Biol Chem, 2008 Apr 4. PMID 18201973
  4. Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Ramon M, et al. Plant Cell Environ, 2009 Aug. PMID 19344332
  5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings provide insight into the function of TPS5-dependent trehalose metabolism in plant basal defense responses.
    Title: Trehalose phosphate synthase 5-dependent trehalose metabolism modulates basal defense responses in Arabidopsis thaliana.
  2. 2-deoxyglucose stimulates Threonine 49 phosphorylation of endogenous TPS5 in Arabidopsis cells.
    Title: Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_117886.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
NOT enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables trehalose-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in trehalose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
trehalose phosphatase/synthase 5
NP_567538.1
  • trehalose phosphatase/synthase 5 (TPS5); FUNCTIONS IN: transferase activity, transferring glycosyl groups, trehalose-phosphatase activity; INVOLVED IN: trehalose biosynthetic process, metabolic process; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HAD-superfamily hydrolase, subfamily IIB (InterPro:IPR006379), Glycosyl transferase, family 20 (InterPro:IPR001830), Trehalose-phosphatase (InterPro:IPR003337); BEST Arabidopsis thaliana protein match is: UDP-Glycosyltransferase / trehalose-phosphatase family protein (TAIR:AT1G68020.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    9876172..9880386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001341241.1 → NP_001329809.1  trehalose phosphatase/synthase 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23617, Q8GWQ1
    UniProtKB/TrEMBL
    A0A178UUB8, A0A384LAK9, W8PUL2
    Conserved Domains (1) summary
    PLN02205
    Location:1 → 850
    PLN02205; alpha,alpha-trehalose-phosphate synthase [UDP-forming]

  2. NM_117886.3 → NP_567538.1  trehalose phosphatase/synthase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23617, Q8GWQ1
    UniProtKB/TrEMBL
    A0A178UUB8, A0A384LAK9, W8PUL2
    Conserved Domains (1) summary
    PLN02205
    Location:1 → 850
    PLN02205; alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O23617.2

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