MOS6 ARM repeat superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MOS6
Official Full Name: ARM repeat superfamily protein
Primary source: TAIR:AT4G02150
Locus tag: AT4G02150
See related: Araport:AT4G02150
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 6; ATIMPALPHA3; IMPA-3; IMPORTIN ALPHA 3; IMPORTIN ALPHA ISOFORM 3; MODIFIER OF SNC1; T10M13.16; T10M13_16
Summary: Encodes IMPORTIN ALPHA 3. Mutant plants act as suppressors of snc1 response and salicylic acid accumulation. Located in the nucleus. Involved in protein import. Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
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Genomic context

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See MOS6 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (950546..953690, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional requirement of the Arabidopsis importin-alpha nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
Title: Functional requirement of the Arabidopsis importin-α nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [MOS6]
Title: An importin alpha homolog, MOS6, plays an important role in plant innate immunity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001340367.1

Supported by ESTs:

NM_116447.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ARM repeat superfamily protein

NP_192124.1

MODIFIER OF SNC1, 6 (MOS6); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, defense response; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 6 (TAIR:AT1G02690.1); Has 4718 Blast hits to 3432 proteins in 305 species: Archae - 4; Bacteria - 22; Metazoa - 2034; Fungi - 556; Plants - 1321; Viruses - 0; Other Eukaryotes - 781 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

950546..953690 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116447.3 → NP_192124.1 ARM repeat superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192124.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04255, O04294, O49601, Q4JHM3, Q94F55

UniProtKB/TrEMBL

A0A178V578, A0A5S9XP37, A0A654FL77

Conserved Domains (2) summary

COG5064
Location:10 → 529

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:247 → 272

ARM; armadillo repeat [structural motif]
NM_001340367.1 → NP_001328074.1 ARM repeat superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B3H5