MSH4 MUTS-like protein 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MSH4
Official Full Name: MUTS-like protein 4
Primary source: TAIR:AT4G17380
Locus tag: AT4G17380
See related: Araport:AT4G17380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS MUTS HOMOLOG 4; ARABIDOPSIS MUTS HOMOLOG 4; ATMSH4; DL4725W; FCAALL.423; MUTS HOMOLOG 4; MUTS HOMOLOG 4; MUTS-like protein 4
Summary: Encodes the Arabidopsis homolog of MSH4, a meiosis-specific member of the MutS-homolog family of genes. It is expressed only in floral tissues and only during early meiotic prophase I, preceding the synapsis of homologous chromosomes. It is involved in the early steps of recombination.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Localization of AtMSH5 to the chromatin at mid-prophase I is dependent on expression of AtMSH4.
Title: AtMSH5 partners AtMSH4 in the class I meiotic crossover pathway in Arabidopsis thaliana, but is not required for synapsis.

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NM_001341219.1

NM_117842.3

Function	Evidence Code	Pubs
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic mismatch repair involved in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mismatch repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

NP_193469.2

MUTS-like protein 4 (MSH4); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, synapsis, meiotic prophase I; LOCATED IN: condensed nuclear chromosome; EXPRESSED IN: flower, sporocyte; EXPRESSED DURING: petal differentiation and expansion stage, IL.00 inflorescence just visible; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS, core (InterPro:IPR007696); BEST Arabidopsis thaliana protein match is: MUTS homolog 2 (TAIR:AT3G18524.1); Has 13303 Blast hits to 13154 proteins in 2712 species: Archae - 169; Bacteria - 9120; Metazoa - 661; Fungi - 837; Plants - 451; Viruses - 3; Other Eukaryotes - 2062 (source: NCBI BLink).

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