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RPP4 Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827395, updated on 18-Sep-2024

Summary

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Official Symbol
RPP4
Official Full Name
Disease resistance protein (TIR-NBS-LRR class) family
Primary source
TAIR:AT4G16860
Locus tag
AT4G16860
See related
Araport:AT4G16860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DL4460C; FCAALL.47; recognition of peronospora parasitica 4
Summary
Confers resistance to Peronospora parasitica. RPP4 is coordinately regulated by transcriptional activation and RNA silencing.
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Genomic context

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See RPP4 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Sequence:
Chromosome: 4; NC_003075.7 (9488466..9495837, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) family protein Neighboring gene pseudo Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gain-of-function mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low temperature. Huang X, et al. Plant Physiol, 2010 Oct. PMID 20699401, Free PMC Article
  2. Arabidopsis HSP90 protein modulates RPP4-mediated temperature-dependent cell death and defense responses. Bao F, et al. New Phytol, 2014 Jun. PMID 24611624
  3. Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components. van der Biezen EA, et al. Plant J, 2002 Feb. PMID 11846877
  4. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation. Xia S, et al. Plant Physiol, 2013 Jul. PMID 23690534, Free PMC Article
  5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via histone H3 lysine trimethylation.
    Title: Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation.
  2. An amino acid substitution in RPP4 leads to a cold temperature-dependent gain-of-function phenotype.
    Title: A gain-of-function mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low temperature.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001341144.1
NM_117790.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables LRR domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Disease resistance protein (TIR-NBS-LRR class) family
NP_193420.2
  • recognition of peronospora parasitica 4 (RPP4); FUNCTIONS IN: LRR domain binding; INVOLVED IN: defense response to fungus, incompatible interaction, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT4G16920.1); Has 24682 Blast hits to 14766 proteins in 601 species: Archae - 8; Bacteria - 1131; Metazoa - 1818; Fungi - 127; Plants - 20736; Viruses - 36; Other Eukaryotes - 826 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    9488466..9495837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117790.4 → NP_193420.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193420.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JNA9, O23527, O23528, Q8GW40, Q8L843, Q8S4Q0
    UniProtKB/TrEMBL
    A0A346XQJ3
    Conserved Domains (5) summary
    PLN03210
    Location:13 → 1081
    PLN03210; Resistant to P. syringae 6; Provisional
    sd00033
    Location:609 → 631
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:13 → 175
    TIR; TIR domain
    pfam07725
    Location:608 → 626
    LRR_3; Leucine Rich Repeat
    pfam13401
    Location:206 → 306
    AAA_22; AAA domain

  2. NM_001341144.1 → NP_001328661.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B5C3, A0A346XQK7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4JNA9.1

Gene LinkOut

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