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FCA flowering time control protein FCA [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827323, updated on 18-Sep-2024

Summary

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Official Symbol
FCA
Official Full Name
flowering time control protein FCA
Primary source
TAIR:AT4G16280
Locus tag
AT4G16280
See related
Araport:AT4G16280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BETA; DELTA AND GAMMA; DL4180C; FCAALL.331; FLOWERING TIME CONTROL PROTEIN FCA ALPHA
Summary
Involved in the promotion of the transition of the vegetative meristem to reproductive development. Four forms of the protein (alpha, beta, delta and gamma) are produced by alternative splicing. Involved in RNA-mediated chromatin silencing. At one point it was believed to act as an abscisic acid receptor but the paper describing that function was retracted.
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Genomic context

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See FCA in Genome Data Viewer
Location:
chromosome: 4
Exon count:
22
Sequence:
Chromosome: 4; NC_003075.7 (9206597..9214981, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNA polymerases M/15 Kd subunit Neighboring gene miscRNA Neighboring gene peroxidase superfamily protein Neighboring gene S-protein homologue 1 Neighboring gene LSD1-like 3 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FCA, a gene controlling flowering time in Arabidopsis, encodes a protein containing RNA-binding domains. Macknight R, et al. Cell, 1997 May 30. PMID 9182761
  2. Analysis of flowering time control in Arabidopsis by comparison of double and triple mutants. Reeves PH, et al. Plant Physiol, 2001 Jul. PMID 11457959, Free PMC Article
  3. An FCA-mediated epigenetic route towards thermal adaptation of autotrophic development in plants. Lee HJ, et al. BMB Rep, 2017 Jul. PMID 28454607, Free PMC Article
  4. FCA does not bind abscisic acid. Risk JM, et al. Nature, 2008 Dec 11. PMID 19078995
  5. Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA. Simpson GG, et al. Plant Cell, 2010 Nov. PMID 21075770, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level.
    Title: Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level.
  2. R-loop resolution promotes co-transcriptional chromatin silencing.
    Title: R-loop resolution promotes co-transcriptional chromatin silencing.
  3. FCA binding of COOLAIR and SSU72 at FLC is critical for PRC2 enrichment and H3K27me3 deposition in Arabidopsis
    Title: PRC2 recruitment and H3K27me3 deposition at FLC require FCA binding of COOLAIR.
  4. an FCA-mediated epigenetic route towards thermal adaptation of autotrophic development in plants
    Title: An FCA-mediated epigenetic route towards thermal adaptation of autotrophic development in plants.
  5. regulation of YUC8 expression tunes down PIF4-induced architectural changes to achieve thermal adaptation of stem growth at high ambient temperature
    Title: FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis.
  6. FCA plays a role in the induction of thermotolerance by triggering antioxidant accumulation under heat stress conditions.
    Title: The Arabidopsis thaliana RNA-binding protein FCA regulates thermotolerance by modulating the detoxification of reactive oxygen species.
  7. Data suggest that the FCA-miR172 regulon provides an adaptive strategy that fine tunes the onset of flowering under fluctuating ambient temperature conditions.
    Title: Arabidopsis RNA-binding protein FCA regulates microRNA172 processing in thermosensory flowering.
  8. FCA and FPA play important roles in the A. thaliana genome in RNA 3' processing and transcription termination, thus limiting intergenic transcription.
    Title: RNA 3' processing functions of Arabidopsis FCA and FPA limit intergenic transcription.
  9. Data show distinct layers of FCA regulation that involve sequences within the 5' region that regulate noncanonical translation initiation and alter the expression profile.
    Title: Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA.
  10. FCA does not bind ABA
    Title: FCA does not bind abscisic acid.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001341092.1
NM_117725.3
NM_148347.2
NM_179211.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables abscisic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryo sac development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulatory ncRNA-mediated heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
flowering time control protein FCA
NP_001319956.1
  • FCA; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), WW/Rsp5/WWP (InterPro:IPR001202), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_193363.4
  • FCA; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), Paraneoplastic encephalomyelitis antigen (InterPro:IPR002343), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_680713.2
  • RNA binding;abscisic acid binding; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), WW/Rsp5/WWP (InterPro:IPR001202), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1).
NP_849542.2
  • FCA; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), WW/Rsp5/WWP (InterPro:IPR001202), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    9206597..9214981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_148347.2 → NP_680713.2  flowering time control protein FCA [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UWV8, F4JLR7, Q5I5A2
    Conserved Domains (3) summary
    cd00201
    Location:522 → 549
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd12633
    Location:46 → 125
    RRM1_FCA; RNA recognition motif 1 in plant flowering time control protein FCA and similar proteins
    cd12637
    Location:137 → 216
    RRM2_FCA; RNA recognition motif 2 in plant flowering time control protein FCA and similar proteins

  2. NM_001341092.1 → NP_001319956.1  flowering time control protein FCA [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JLR8, F4JLR9, O04424, O04425, O04727, O23475
    UniProtKB/TrEMBL
    A0A178UWV8, Q5I5A2
    Conserved Domains (4) summary
    cd00201
    Location:597 → 624
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd12633
    Location:121 → 200
    RRM1_FCA; RNA recognition motif 1 in plant flowering time control protein FCA and similar proteins
    cd12637
    Location:212 → 291
    RRM2_FCA; RNA recognition motif 2 in plant flowering time control protein FCA and similar proteins
    cl25617
    Location:121 → 497
    LSM_int_assoc; LSM-interacting associated unstructured

  3. NM_117725.3 → NP_193363.4  flowering time control protein FCA [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_193363.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04425
    Conserved Domains (2) summary
    cd12633
    Location:121 → 200
    RRM1_FCA; RNA recognition motif 1 in plant flowering time control protein FCA and similar proteins
    cd12637
    Location:212 → 291
    RRM2_FCA; RNA recognition motif 2 in plant flowering time control protein FCA and similar proteins

  4. NM_179211.3 → NP_849542.2  flowering time control protein FCA [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849542.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UV10
    Conserved Domains (2) summary
    cd00201
    Location:355 → 382
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cl17169
    Location:1 → 49
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O04425.3

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