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dihydrolipoamide dehydrogenase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827307, updated on 11-Oct-2024

Summary

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Official Full Name
dihydrolipoamide dehydrogenase
Primary source
TAIR:AT4G16155
Locus tag
AT4G16155
See related
Araport:AT4G16155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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Genomic context

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Location:
chromosome: 4
Exon count:
15
Sequence:
Chromosome: 4; NC_003075.7 (9153570..9157133, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene cAMP-regulated phosphoprotein 19-related protein Neighboring gene calmodulin-binding transcription activator 5 Neighboring gene Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 family protein Neighboring gene Leucine-rich repeat (LRR) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis. Chen W, et al. Plant Physiol, 2010 Jul. PMID 20488895, Free PMC Article
  2. Molecular evidence of a unique lipoamide dehydrogenase in plastids: analysis of plastidic lipoamide dehydrogenase from Arabidopsis thaliana. Lutziger I, et al. FEBS Lett, 2000 Oct 27. PMID 11056213
  3. Thioredoxins o1 and h2 jointly adjust mitochondrial dihydrolipoamide dehydrogenase-dependent pathways towards changing environments. Timm S, et al. Plant Cell Environ, 2024 Jul. PMID 38518065
  4. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
  5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thioredoxins o1 and h2 jointly adjust mitochondrial dihydrolipoamide dehydrogenase-dependent pathways towards changing environments.
    Title: Thioredoxins o1 and h2 jointly adjust mitochondrial dihydrolipoamide dehydrogenase-dependent pathways towards changing environments.
  2. These findings show that the plastidial LIPOAMIDE DEHYDROGENASE, ptLPD, isoforms are critical in vivo determinants of arsenite-mediated arsenic sensitivity in Arabidopsis and possible strategic targets for increasing arsenic tolerance. [ptLPD2]
    Title: Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_117711.8

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dihydrolipoyl dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyl dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to arsenic-containing substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
dihydrolipoamide dehydrogenase
NP_567487.5
  • dihydrolipoyl dehydrogenases; FUNCTIONS IN: dihydrolipoyl dehydrogenase activity; INVOLVED IN: oxidation reduction, cell redox homeostasis; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), Mercuric reductase (InterPro:IPR000815), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: lipoamide dehydrogenase 1 (TAIR:AT3G16950.1); Has 29334 Blast hits to 29301 proteins in 3032 species: Archae - 559; Bacteria - 20043; Metazoa - 811; Fungi - 377; Plants - 519; Viruses - 0; Other Eukaryotes - 7025 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    9153570..9157133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_117711.8 → NP_567487.5  dihydrolipoamide dehydrogenase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4JLP5, Q9M5K4
    UniProtKB/TrEMBL
    A0A654FPS4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4JLP5.2

Gene LinkOut

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