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ESD4 Cysteine proteinases superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827269, updated on 18-Sep-2024

Summary

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Official Symbol
ESD4
Official Full Name
Cysteine proteinases superfamily protein
Primary source
TAIR:AT4G15880
Locus tag
AT4G15880
See related
Araport:AT4G15880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATESD4; DL3980W; EARLY IN SHORT DAYS 4; FCAALL.406
Summary
EARLY IN SHORT DAYS 4 Arabidopsis mutant shows extreme early flowering and alterations in shoot development. It encodes a SUMO protease, located predominantly at the periphery of the nucleus. Accelerates the transition from vegetative growth to flowering. Probably acts in the same pathway as NUA in affecting flowering time, vegetative and inflorescence development.
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Genomic context

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See ESD4 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Sequence:
Chromosome: 4; NC_003075.7 (9012552..9016179)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene terpene synthase 1 Neighboring gene kinesin motor protein-like protein Neighboring gene binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates. Murtas G, et al. Plant Cell, 2003 Oct. PMID 14507998, Free PMC Article
  2. Distinct roles for Arabidopsis SUMO protease ESD4 and its closest homolog ELS1. Hermkes R, et al. Planta, 2011 Jan. PMID 20922545, Free PMC Article
  3. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis. Xie B, et al. New Phytol, 2024 Jan. PMID 37786257, Free PMC Article
  4. Activation of NLR-Mediated Autoimmunity in Arabidopsis Early in Short Days 4 Mutant. Huang X, et al. Front Plant Sci, 2022. PMID 35693184, Free PMC Article
  5. SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis. Colby T, et al. Plant Physiol, 2006 Sep. PMID 16920872, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
    Title: NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
  2. Two A. thaliana SUMO proteases showing close sequence similarity have distinct in vivo functions.
    Title: Distinct roles for Arabidopsis SUMO protease ESD4 and its closest homolog ELS1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_117680.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Cysteine proteinases superfamily protein
NP_567478.1
  • EARLY IN SHORT DAYS 4 (ESD4); CONTAINS InterPro DOMAIN/s: Peptidase C48, SUMO/Sentrin/Ubl1 (InterPro:IPR003653); BEST Arabidopsis thaliana protein match is: UB-like protease 1A (TAIR:AT3G06910.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    9012552..9016179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001341077.1 → NP_001328371.1  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B4F2, A0A654FPS3

  2. NM_117680.4 → NP_567478.1  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567478.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFG4, O23439, Q70G10, Q7DLT0, Q94F30
    UniProtKB/TrEMBL
    A0A654FPS3
    Conserved Domains (1) summary
    PLN03189
    Location:1 → 489
    PLN03189; Protease specific for SMALL UBIQUITIN-RELATED MODIFIER (SUMO); Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94F30.1

Gene LinkOut

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