ORC1A origin recognition complex 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: ORC1A
Official Full Name: origin recognition complex 1
Primary source: TAIR:AT4G14700
Locus tag: AT4G14700
See related: Araport:AT4G14700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATORC1A; DL3390W; FCAALL.93; origin recognition complex 1
Summary: Encodes origin of replication complex 1a subunit.The protein contains a PHD domain,binds methylated DNA and appears to function as a transcriptional activator.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition.
Title: Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition.
ORC1 functions as a transcriptional activator of a subset of genes, the promoters of which are preferentially bound by ORC1
Title: Arabidopsis ORC1 is a PHD-containing H3K4me3 effector that regulates transcription.
ORC1 and Mcm3 proteins are required for DNA replication in protein extracts from human cells
Title: DNA replication in protein extracts from human cells requires ORC and Mcm proteins.
ORC1a and ORC1b are regulated by the E2F/DP family of transcription factors and AtORC1b promoter is active exclusively in proliferating cells
Title: The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells.
ORC1a and ORC1b are regulated by the E2F/DP family of transcription factors and AtORC1a is preferentially expressed in endoreplicating cells. [ORC1a]
Title: The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_117553.2

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables double-stranded methylated DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
part_of origin recognition complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_567440.1

origin recognition complex 1 (ORC1A); CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Zinc finger, PHD-type (InterPro:IPR001965), Origin recognition complex, subunit 1 (InterPro:IPR020793), ATPase, AAA+ type, core (InterPro:IPR003593), Bromo adjacent homology (BAH) domain (InterPro:IPR001025), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: origin of replication complex 1B (TAIR:AT4G12620.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

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