SHM4 serine hydroxymethyltransferase 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: SHM4
Official Full Name: serine hydroxymethyltransferase 4
Primary source: TAIR:AT4G13930
Locus tag: AT4G13930
See related: Araport:AT4G13930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DL3005C; FCAALL.160; serine hydroxymethyltransferase 4; SERINE HYDROXYMETHYLTRANSFERASE 4
Summary: Encodes a serine hydroxymethyltransferase maximally expressed in root
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Structural modeling of SHM1, SHM2, and SHM4 presented features that may explain the activity differences between the mitochondrial and cytosolic isozymes.
Title: Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_117467.4

Function	Evidence Code	Pubs
enables glycine hydroxymethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables salicylic acid binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in glycine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

NP_193129.1

serine hydroxymethyltransferase 4 (SHM4); FUNCTIONS IN: pyridoxal phosphate binding, glycine hydroxymethyltransferase activity, catalytic activity; INVOLVED IN: response to cadmium ion, glycine metabolic process, L-serine metabolic process; LOCATED IN: cytosol, plasma membrane, membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Serine hydroxymethyltransferase, pyridoxal phosphate binding site (InterPro:IPR019798), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Serine hydroxymethyltransferase (InterPro:IPR001085); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT4G13890.1); Has 11689 Blast hits to 11661 proteins in 2862 species: Archae - 259; Bacteria - 6437; Metazoa - 341; Fungi - 289; Plants - 375; Viruses - 6; Other Eukaryotes - 3982 (source: NCBI BLink).