HMGS hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HMGS
Official Full Name: hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase
Primary source: TAIR:AT4G11820
Locus tag: AT4G11820
See related: Araport:AT4G11820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EMB2778; EMBRYO DEFECTIVE 2778; FKP1; FLAKY POLLEN 1; HMG-COA SYNTHASE; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; MVA1; T26M18.30; T26M18_30
Summary: Encodes a protein with hydroxymethylglutaryl-CoA synthase activity which was characterized by phenotypical complementation of the S. cerevisiae mutant.
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Genomic context

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See HMGS in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 14

Sequence:: Chromosome: 4; NC_003075.7 (7108884..7112480, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of HMG-CoA synthase promotes Arabidopsis root growth and adversely affects glucosinolate biosynthesis.
Title: Overexpression of HMG-CoA synthase promotes Arabidopsis root growth and adversely affects glucosinolate biosynthesis.
FLAKY POLLEN1 is required for organelle development in tapetal cells and pollen coat formation. [FKP1]
Title: The Arabidopsis FLAKY POLLEN1 gene encodes a 3-hydroxy-3-methylglutaryl-coenzyme A synthase required for development of tapetum-specific organelles and fertility of pollen grains.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001340735.1

Supported by ESTs:

NM_117251.3

Supported by ESTs:

NM_179030.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
NOT enables acetyl-CoA C-acetyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hydroxymethylglutaryl-CoA synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hydroxymethylglutaryl-CoA synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, mevalonate pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase

NP_001319906.1

HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMGS); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-coenzyme A synthase C-terminal (InterPro:IPR013746), Thiolase-like (InterPro:IPR016039), Hydroxymethylglutaryl-coenzyme A synthase, N-terminal (InterPro:IPR013528), Hydroxymethylglutaryl-CoA synthase, eukaryotic (InterPro:IPR010122), Hydroxymethylglutaryl-coenzyme A synthase, active site (InterPro:IPR000590); Has 2141 Blast hits to 2138 proteins in 847 species: Archae - 222; Bacteria - 1037; Metazoa - 301; Fungi - 182; Plants - 116; Viruses - 0; Other Eukaryotes - 283 (source: NCBI BLink).

NP_192919.1

MVA1; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Hydroxymethylglutaryl-coenzyme A synthase C-terminal (InterPro:IPR013746), Hydroxymethylglutaryl-coenzyme A synthase, N-terminal (InterPro:IPR013528), Hydroxymethylglutaryl-CoA synthase, eukaryotic (InterPro:IPR010122), Hydroxymethylglutaryl-coenzyme A synthase, active site (InterPro:IPR000590); Has 2176 Blast hits to 2172 proteins in 850 species: Archae - 228; Bacteria - 1039; Metazoa - 300; Fungi - 184; Plants - 117; Viruses - 0; Other Eukaryotes - 308 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7108884..7112480 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117251.3 → NP_192919.1 hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192919.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54873, Q8L721, Q9S707

UniProtKB/TrEMBL

A0A178V7M2, A0A5S9XS43

Conserved Domains (3) summary

PLN02577
Location:1 → 461

PLN02577; hydroxymethylglutaryl-CoA synthase

pfam08540
Location:175 → 451

HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

cl09938
Location:4 → 174

cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
NM_179030.1 → NP_849361.1 hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849361.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V7M2, A0A5S9XS43

Conserved Domains (3) summary

PLN02577
Location:1 → 406

PLN02577; hydroxymethylglutaryl-CoA synthase

pfam08540
Location:120 → 396

HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

cl09938
Location:1 → 119

cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
NM_001340735.1 → NP_001319906.1 hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V7M2, A0A5S9XS43