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TL29 ascorbate peroxidase 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826480, updated on 18-Sep-2024

Summary

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Official Symbol
TL29
Official Full Name
ascorbate peroxidase 4
Primary source
TAIR:AT4G09010
Locus tag
AT4G09010
See related
Araport:AT4G09010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
APX4; ascorbate peroxidase 4; F23J3.40; F23J3_40; thylakoid lumen 29
Summary
Encodes a thylakoid lumen protein that was initially believed to act as a microsomal ascorbate peroxidase APX4 but to date, no evidence of enzymatic activity has been found.
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Genomic context

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See TL29 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (5777397..5779572, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene general regulatory factor 1 Neighboring gene ncRNA Neighboring gene Mitochondrial ribosomal protein L27 Neighboring gene isoamylase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The APX4 locus regulates seed vigor and seedling growth in Arabidopsis thaliana. Wang YY, et al. Planta, 2014 Apr. PMID 24407512
  2. Crystal structure of the TL29 protein from Arabidopsis thaliana: an APX homolog without peroxidase activity. Lundberg E, et al. J Struct Biol, 2011 Oct. PMID 21798352
  3. The TL29 protein is lumen located, associated with PSII and not an ascorbate peroxidase. Granlund I, et al. Plant Cell Physiol, 2009 Nov. PMID 19828564
  4. Characterization of the Free and Membrane-Associated Fractions of the Thylakoid Lumen Proteome in Arabidopsis thaliana. Gollan PJ, et al. Int J Mol Sci, 2021 Jul 29. PMID 34360890, Free PMC Article
  5. Thioredoxin targets of the plant chloroplast lumen and their implications for plastid function. Hall M, et al. Proteomics, 2010 Mar. PMID 20049866

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APX4 is involved in the reactive oxygen species (ROS)-scavenging process in chloroplasts.
    Title: The APX4 locus regulates seed vigor and seedling growth in Arabidopsis thaliana.
  2. Crystal structure of the TL29 protein from Arabidopsis thaliana: an APX homolog without peroxidase activity
    Title: Crystal structure of the TL29 protein from Arabidopsis thaliana: an APX homolog without peroxidase activity.
  3. TL29 protein is a lumen-located subunit associated with PSII and not a peroxidase involved in reactive oxygen species stress response. [TL29]
    Title: The TL29 protein is lumen located, associated with PSII and not an ascorbate peroxidase.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001340606.1
NM_001340607.1
NM_116970.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
NOT enables L-ascorbate peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast thylakoid HDA PubMed 
located_in chloroplast thylakoid lumen HDA PubMed 
located_in chloroplast thylakoid lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast thylakoid membrane HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in thylakoid HDA PubMed 
located_in thylakoid lumen HDA PubMed 

General protein information

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Preferred Names
ascorbate peroxidase 4
NP_192640.1
  • ascorbate peroxidase 4 (APX4); FUNCTIONS IN: peroxidase activity, heme binding; INVOLVED IN: oxidation reduction, response to oxidative stress; LOCATED IN: in 7 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 5 (TAIR:AT4G35970.1); Has 1182 Blast hits to 1180 proteins in 264 species: Archae - 20; Bacteria - 119; Metazoa - 0; Fungi - 348; Plants - 604; Viruses - 0; Other Eukaryotes - 91 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    5777397..5779572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116970.3 → NP_192640.1  ascorbate peroxidase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P82281, Q7XZP6, Q9M0S6
    UniProtKB/TrEMBL
    A0A178UTM3, A0A5S9XSG0
    Conserved Domains (1) summary
    cd00314
    Location:96 → 274
    plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases

  2. NM_001340607.1 → NP_001329836.1  ascorbate peroxidase 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UTM3, A0A1P8B8Y3

  3. NM_001340606.1 → NP_001329837.1  ascorbate peroxidase 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UTM3, A0A1P8B8W6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82281.2

Gene LinkOut

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