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MEKK3 MAPK/ERK kinase kinase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826406, updated on 18-Sep-2024

Summary

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Official Symbol
MEKK3
Official Full Name
MAPK/ERK kinase kinase 3
Primary source
TAIR:AT4G08470
Locus tag
AT4G08470
See related
Araport:AT4G08470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MAPK/ERK kinase kinase 3; MAPKKK10; T15F16.2; T15F16_2
Summary
Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are described in Trends in Plant Science 2002, 7(7):301.
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Genomic context

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See MEKK3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Sequence:
Chromosome: 4; NC_003075.7 (5383688..5387260, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene BTB/POZ domain-containing protein Neighboring gene hypothetical protein (DUF1644) Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase kinase kinase 9 Neighboring gene Defensin-like (DEFL) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Back From the Dead: The Atypical Kinase Activity of a Pseudokinase Regulator of Cation Fluxes During Inducible Immunity. Brauer EK, et al. Front Plant Sci, 2022. PMID 36035673, Free PMC Article
  2. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

NM_001340589.1
NM_116916.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
MAPK/ERK kinase kinase 3
NP_192587.1
  • MAPK/ERK kinase kinase 3 (MEKK3); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: MAPK/ERK kinase kinase 1 (TAIR:AT4G08500.1); Has 127289 Blast hits to 125542 proteins in 4465 species: Archae - 126; Bacteria - 13573; Metazoa - 48244; Fungi - 12466; Plants - 31976; Viruses - 540; Other Eukaryotes - 20364 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    5383688..5387260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001340588.1 → NP_001329232.1  MAPK/ERK kinase kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V2Y2, A0A1P8B722

  2. NM_116916.4 → NP_192587.1  MAPK/ERK kinase kinase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192587.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81473, O82650, Q84W26, Q9M0T3
    UniProtKB/TrEMBL
    A0A5S9XQE8
    Conserved Domains (1) summary
    cl21453
    Location:302 → 557
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001340589.1 → NP_001329233.1  MAPK/ERK kinase kinase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B727, A0A5S9XQE8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M0T3.1

Gene LinkOut

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