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AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825864, updated on 18-Sep-2024

Summary

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Official Full Name
AMP-dependent synthetase and ligase family protein
Primary source
TAIR:AT4G05160
Locus tag
AT4G05160
See related
Araport:AT4G05160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
C17L7.80; C17L7_80
Summary
Encodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At4g05160 preferentially activates fatty acids with medium chain length (C6:0 and C7:0) as well as even-numbered long-chain fatty acids (C14:0, C16:0 and C18:0). At4g05160 was also able to catalyze the conversion of OPC-6:0 to its CoA ester and is therefore thought to be involved in the peroxisomal beta-oxidation steps of jasmonic acid biosynthesis.
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Genomic context

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Location:
chromosome: 4
Exon count:
6
Sequence:
Chromosome: 4; NC_003075.7 (2664314..2666973)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Octicosapeptide/Phox/Bem1p family protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene photosystem II subunit Q-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new type of peroxisomal acyl-coenzyme A synthetase from Arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid. Schneider K, et al. J Biol Chem, 2005 Apr 8. PMID 15677481
  2. Jasmonates meet fatty acids: functional analysis of a new acyl-coenzyme A synthetase family from Arabidopsis thaliana. Kienow L, et al. J Exp Bot, 2008. PMID 18267944
  3. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
  4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data demonstrate that At4g05160 and At5g63380 have the capacity to contribute to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors.
    Title: A new type of peroxisomal acyl-coenzyme A synthetase from Arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_116755.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 4-coumarate-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fatty-acyl-CoA synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in auxin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in auxin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within jasmonic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AMP-dependent synthetase and ligase family protein
NP_192425.1
  • AMP-dependent synthetase and ligase family protein; FUNCTIONS IN: 4-coumarate-CoA ligase activity, fatty-acyl-CoA synthase activity; INVOLVED IN: jasmonic acid biosynthetic process; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: OPC-8:0 CoA ligase1 (TAIR:AT1G20510.1); Has 86858 Blast hits to 79133 proteins in 3797 species: Archae - 1159; Bacteria - 54259; Metazoa - 3570; Fungi - 4802; Plants - 2877; Viruses - 1; Other Eukaryotes - 20190 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    2664314..2666973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116755.5 → NP_192425.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192425.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9M0X9
    UniProtKB/TrEMBL
    A0A178UXS2, A0A5S9XQ10, A0A654FLR8
    Conserved Domains (1) summary
    cd05904
    Location:21 → 536
    4CL; 4-Coumarate-CoA Ligase (4CL)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M0X9.1

Gene LinkOut

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