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RMA1 RING membrane-anchor 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825654, updated on 18-Sep-2024

Summary

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Official Symbol
RMA1
Official Full Name
RING membrane-anchor 1
Primary source
TAIR:AT4G03510
Locus tag
AT4G03510
See related
Araport:AT4G03510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRMA1; F9H3.14; F9H3_14; RING membrane-anchor 1
Summary
RMA1 encodes a novel 28 kDa protein with a RING finger motif and a C-terminal membrane-anchoring domain that is involved in the secretory pathway. Has E3 ubiquitin ligase activity.
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Genomic context

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See RMA1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_003075.7 (1557120..1559437, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein Neighboring gene uncharacterized protein Neighboring gene Ankyrin repeat family protein Neighboring gene uncharacterized protein Neighboring gene Thioredoxin superfamily protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RMA1, an Arabidopsis thaliana gene whose cDNA suppresses the yeast sec15 mutation, encodes a novel protein with a RING finger motif and a membrane anchor. Matsuda N, et al. Plant Cell Physiol, 1998 May. PMID 9664717
  2. Drought stress-induced Rma1H1, a RING membrane-anchor E3 ubiquitin ligase homolog, regulates aquaporin levels via ubiquitination in transgenic Arabidopsis plants. Lee HK, et al. Plant Cell, 2009 Feb. PMID 19234086, Free PMC Article
  3. Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase. Son O, et al. Plant Cell Rep, 2009 Apr. PMID 19224217
  4. Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. Matsuda N, et al. J Cell Sci, 2001 May. PMID 11329381
  5. Ubiquitin ligase OsRINGzf1 regulates drought resistance by controlling the turnover of OsPIP2;1. Chen S, et al. Plant Biotechnol J, 2022 Sep. PMID 35587579, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RMA1, RMA2 and RMA3 all have E3 ubiquitin ligase activity and are localized to the endoplasmic reticulum.
    Title: Characterization of three Arabidopsis homologs of human RING membrane anchor E3 ubiquitin ligase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001340463.1
NM_001340464.1
NM_116589.3
NM_202777.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within secretion by cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
RING membrane-anchor 1
NP_001319862.1
  • RING membrane-anchor 1 (RMA1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING membrane-anchor 2 (TAIR:AT4G28270.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_192260.1
  • RING membrane-anchor 1 (RMA1); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING membrane-anchor 2 (TAIR:AT4G28270.1); Has 3991 Blast hits to 3981 proteins in 266 species: Archae - 0; Bacteria - 0; Metazoa - 2157; Fungi - 553; Plants - 874; Viruses - 19; Other Eukaryotes - 388 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    1557120..1559437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116589.3 → NP_192260.1  RING membrane-anchor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192260.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64425
    UniProtKB/TrEMBL
    A0A178V3K7, A0A5S9XPV8
    Conserved Domains (2) summary
    PLN03208
    Location:40 → 249
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cd00162
    Location:47 → 100
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_001340463.1 → NP_001319862.1  RING membrane-anchor 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64425
    UniProtKB/TrEMBL
    A0A178V3K7, A0A5S9XPV8

  3. NM_202777.2 → NP_974506.1  RING membrane-anchor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974506.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64425
    UniProtKB/TrEMBL
    A0A178V3K7, A0A5S9XPV8
    Conserved Domains (2) summary
    PLN03208
    Location:40 → 249
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cd00162
    Location:47 → 100
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  4. NM_001340464.1 → NP_001329467.1  RING membrane-anchor 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64425
    UniProtKB/TrEMBL
    A0A178V3K7, A0A5S9XPV8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O64425.1

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