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ATHM2 Thioredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825653, updated on 18-Sep-2024

Summary

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Official Symbol
ATHM2
Official Full Name
Thioredoxin superfamily protein
Primary source
TAIR:AT4G03520
Locus tag
AT4G03520
See related
Araport:AT4G03520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F9H3.15; F9H3_15; T5L23.1; thioredoxin m2; TRXm2
Summary
Encodes a redox activated co-chaperone, chloroplast localized thioredoxin, similar to prokaryotic types.
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Genomic context

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See ATHM2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Sequence:
Chromosome: 4; NC_003075.7 (1562203..1564204, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein Neighboring gene Ankyrin repeat family protein Neighboring gene uncharacterized protein Neighboring gene RING membrane-anchor 1 Neighboring gene pseudo Neighboring gene Uncharacterized protein family (UPF0497)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis mitochondrial voltage-dependent anion channel 3 (AtVDAC3) protein interacts with thioredoxin m2. Zhang M, et al. FEBS Lett, 2015 May 8. PMID 25862497
  2. M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis. Da Q, et al. Plant Cell Rep, 2018 Feb. PMID 29080907
  3. Evidence for a role of chloroplastic m-type thioredoxins in the biogenesis of photosystem II in Arabidopsis. Wang P, et al. Plant Physiol, 2013 Dec. PMID 24151299, Free PMC Article
  4. Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol. Meyer T, et al. Plant J, 2011 Jun. PMID 21309870
  5. Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes involves interaction with Trx m2 in the cytosol. Hölscher C, et al. Mol Plant, 2014 Jan. PMID 24008768

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the m-type thioredoxins TRX-m1, TRX-m2, and TRX-m4 (TRX-ms) interact with the xanthophyll cycle enzyme zeaxanthin epoxidase (ZE) and are required for maintaining the redox-dependent stabilization of ZE.
    Title: M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis.
  2. Results indicate that both AtVDAC3 and AtTrx m2 are involved in ROS signaling and play opposite roles in NaCl stress response.
    Title: Arabidopsis mitochondrial voltage-dependent anion channel 3 (AtVDAC3) protein interacts with thioredoxin m2.
  3. These results suggest an important role for TRX m1, TRX m2, and TRX m4 proteins in the biogenesis of photosystem II.
    Title: Evidence for a role of chloroplastic m-type thioredoxins in the biogenesis of photosystem II in Arabidopsis.
  4. targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes
    Title: Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to chloroplasts and peroxisomes involves interaction with Trx m2 in the cytosol.
  5. Yeast two-hybrid analyses revealed selective protein-protein interactions of G6PD1 (glucose-6-phosphate dehydrogenase 1) with catalytically inactive G6PD4, and of both G6PD isoforms with plastid-destined thioredoxin M2.
    Title: Alternative targeting of Arabidopsis plastidic glucose-6-phosphate dehydrogenase G6PD1 involves cysteine-dependent interaction with G6PD4 in the cytosol.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001160731.2
NM_116590.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in chloroplast thylakoid membrane HDA PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in thylakoid HDA PubMed 

General protein information

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Preferred Names
Thioredoxin superfamily protein
NP_001154203.1
  • ATHM2; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like fold (InterPro:IPR012336), Thioredoxin domain (InterPro:IPR013766); BEST Arabidopsis thaliana protein match is: thioredoxin M-type 1 (TAIR:AT1G03680.1); Has 9201 Blast hits to 9185 proteins in 2237 species: Archae - 146; Bacteria - 6732; Metazoa - 24; Fungi - 110; Plants - 264; Viruses - 0; Other Eukaryotes - 1925 (source: NCBI BLink).
NP_192261.1
  • ATHM2; FUNCTIONS IN: enzyme activator activity; INVOLVED IN: response to oxidative stress, positive regulation of catalytic activity; LOCATED IN: thylakoid, chloroplast thylakoid membrane, chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin (InterPro:IPR005746), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin M-type 1 (TAIR:AT1G03680.1); Has 20603 Blast hits to 19509 proteins in 2977 species: Archae - 276; Bacteria - 10688; Metazoa - 2669; Fungi - 1127; Plants - 1883; Viruses - 7; Other Eukaryotes - 3953 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    1562203..1564204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116590.4 → NP_192261.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192261.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56YG4, Q8LG26, Q9SEU8, Q9ZT79
    UniProtKB/TrEMBL
    A0A178V0B8, A0A5S9XPK2, A0A654FLK3, A0A7G2EZV8
    Conserved Domains (1) summary
    TIGR01068
    Location:85 → 185
    thioredoxin

  2. NM_001160731.2 → NP_001154203.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JG94
    Conserved Domains (1) summary
    cl00388
    Location:1 → 71
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SEU8.2

Gene LinkOut

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