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TIR1 F-box/RNI-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825473, updated on 18-Sep-2024

Summary

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Official Symbol
TIR1
Official Full Name
F-box/RNI-like superfamily protein
Primary source
TAIR:AT3G62980
Locus tag
AT3G62980
See related
Araport:AT3G62980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtTIR1; TRANSPORT INHIBITOR RESPONSE 1
Summary
Encodes an auxin receptor that mediates auxin-regulated transcription. It contains leucine-rich repeats and an F-box and interacts with ASK1, ASK2 and AtCUL1 to form SCF-TIR1, an SCF ubiquitin ligase complex. Related to yeast Grr1p and human SKP2 proteins, involved in ubiquitin-mediated processes. Required for normal response to auxin and repressed in response to flagellin. As part of the SCF complex and in the presence of auxin, TIR1 interacts with Aux/IAA transcriptional repressor proteins and mediates their degradation. Mutations in TIR1 block auxin stimulation of flavonoid synthesis.
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Genomic context

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See TIR1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Sequence:
Chromosome: 3; NC_003074.8 (23273065..23276630, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Thioredoxin superfamily protein Neighboring gene zinc finger (C3HC4-type RING finger) family protein Neighboring gene myelin transcription factor-like protein Neighboring gene NPL4-like protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of auxin response by miR393-targeted transport inhibitor response protein 1 is involved in normal development in Arabidopsis. Chen ZH, et al. Plant Mol Biol, 2011 Dec. PMID 22042293
  2. The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p. Ruegger M, et al. Genes Dev, 1998 Jan 15. PMID 9436980, Free PMC Article
  3. Small-molecule agonists and antagonists of F-box protein-substrate interactions in auxin perception and signaling. Hayashi K, et al. Proc Natl Acad Sci U S A, 2008 Apr 8. PMID 18391211, Free PMC Article
  4. Auxin activates the plasma membrane H+-ATPase by phosphorylation during hypocotyl elongation in Arabidopsis. Takahashi K, et al. Plant Physiol, 2012 Jun. PMID 22492846, Free PMC Article
  5. Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions. Prigge MJ, et al. Elife, 2020 Feb 18. PMID 32067636, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis.
    Title: FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signaling in Arabidopsis.
  2. TIR signal promotes interactions between lipase-like proteins and ADR1-L1 receptor and ADR1-L1 oligomerization.
    Title: TIR signal promotes interactions between lipase-like proteins and ADR1-L1 receptor and ADR1-L1 oligomerization.
  3. Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions.
    Title: Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions.
  4. Control of Adventitious Rooting by TIR1/AFB2-Aux/IAA-Dependent Auxin Signaling in Arabidopsis
    Title: A Molecular Framework for the Control of Adventitious Rooting by TIR1/AFB2-Aux/IAA-Dependent Auxin Signaling in Arabidopsis.
  5. In vitro and in vivo protein-protein interaction assays show that NO enhances ASK1 binding to CUL1 and TIR1/AFB2, required for SCF(TIR1/AFB2) assembly.
    Title: Regulation of SCF(TIR1/AFBs) E3 ligase assembly by S-nitrosylation of Arabidopsis SKP1-like1 impacts on auxin signaling.
  6. The miR393-TIR1 molecular regulation pathway appears to be a component of the regulatory control over shoot regeneration from in vitro culture.
    Title: miR393 inhibits in vitro shoot regeneration in Arabidopsis thaliana via repressing TIR1.
  7. TIR1/AFB-Aux/IAA auxin perception mediates rapid cell wall acidification and growth of Arabidopsis hypocotyls.
    Title: TIR1/AFB-Aux/IAA auxin perception mediates rapid cell wall acidification and growth of Arabidopsis hypocotyls.
  8. HSP90 stabilizes auxin receptor TIR1 and ensures plasticity of auxin responses
    Title: HSP90 stabilizes auxin receptor TIR1 and ensures plasticity of auxin responses.
  9. Auxin signaling through TIR1/AFB2/AFB3 mediates feedback regulation of indole-3-acetic acid biosynthesis.
    Title: Auxin signaling through SCF(TIR1/AFBs) mediates feedback regulation of IAA biosynthesis.
  10. We propose oligomerization of TIR1 as a novel regulatory mechanism in the regulation of auxin-mediated plant patterning and development.
    Title: Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_116163.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables auxin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables auxin binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables auxin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in auxin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within lateral root formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to auxin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stamen development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F-box/RNI-like superfamily protein
NP_567135.1
  • TRANSPORT INHIBITOR RESPONSE 1 (TIR1); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364); BEST Arabidopsis thaliana protein match is: GRR1-like protein 1 (TAIR:AT4G03190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    23273065..23276630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116163.4 → NP_567135.1  F-box/RNI-like superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5YZP2, B2CVU0, O24660, Q570C0
    UniProtKB/TrEMBL
    A0A178VA54, A0A5S9XNA6
    Conserved Domains (4) summary
    cd09293
    Location:116 → 224
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:291 → 315
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam18511
    Location:8 → 47
    F-box_5
    pfam18791
    Location:66 → 112
    Transp_inhibit; Transport inhibitor response 1 protein domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q570C0.2

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