CP12-2 CP12 domain-containing protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CP12-2
Official Full Name: CP12 domain-containing protein 2
Primary source: TAIR:AT3G62410
Locus tag: AT3G62410
See related: Araport:AT3G62410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CP12; CP12 DOMAIN-CONTAINING PROTEIN 1; CP12 domain-containing protein 2
Summary: CP12-2 encodes a small peptide found in the chloroplast stroma. It belongs to the CP12 gene family thought to be involved in the formation of a supramolecular complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase (PRK) embedded in the Calvin cycle. CP12-2 is coordinately regulated by light with the photosynthetic GAPDH and PRK. The annotation of this gene is based on article 32494.
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Genomic context

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See CP12-2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 1

Sequence:: Chromosome: 3; NC_003074.8 (23090944..23091580)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conformational Disorder Analysis of the Conditionally Disordered Protein CP12 from Arabidopsis thaliana in Its Different Redox States.
Title: Conformational Disorder Analysis of the Conditionally Disordered Protein CP12 from Arabidopsis thaliana in Its Different Redox States.
Single cp12-1, cp12-2, and cp12-3 mutants do not develop a severe photosynthetic or growth phenotype. In contrast, reductions of both CP12-1 and CP12-2 transcripts lead to reductions in photosynthetic capacity and to slower growth and reduced seed yield. No clear phenotype for CP12-3 was evident.
Title: Arabidopsis CP12 mutants have reduced levels of phosphoribulokinase and impaired function of the Calvin-Benson cycle.
CP12 in oxygen phototrophs needs to be extended beyond light/dark regulation, and include protection of enzymes belonging to Calvine-Benson cycle from oxidative stress.
Title: CP12-mediated protection of Calvin-Benson cycle enzymes from oxidative stress.
All CP12 isoforms formed, in vitro, a supramolecular complex with GAPDH and PRK, with comparable inhibitory effects on both enzyme activities.
Title: In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties.
CP12-1 and CP12-2 expression was detected in the sepals and the style of the flower, while CP12-3 was restricted to the stigma and anthers.
Title: Expression analysis of the Arabidopsis CP12 gene family suggests novel roles for these proteins in roots and floral tissues.
The redox dependence of events leading to supramolecular complexes is consistent with a role of CP12 in coordinating the reversible inactivation of chloroplast enzymes A(4)-GAPDH and PRK during darkness in photosynthetic tissues.
Title: Spontaneous assembly of photosynthetic supramolecular complexes as mediated by the intrinsically unstructured protein CP12.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_116106.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nickel cation binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to anoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of reductive pentose-phosphate cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptide cross-linking via L-cystine	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within reductive pentose-phosphate cycle	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to sucrose	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	HDA more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CP12 domain-containing protein 2

NP_191800.1

CP12 domain-containing protein 2 (CP12-2); FUNCTIONS IN: protein binding; INVOLVED IN: negative regulation of reductive pentose-phosphate cycle, response to light stimulus, reductive pentose-phosphate cycle, peptide cross-linking via L-cystine, response to sucrose stimulus; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function CP12 (InterPro:IPR003823); BEST Arabidopsis thaliana protein match is: CP12 domain-containing protein 1 (TAIR:AT2G47400.1); Has 244 Blast hits to 244 proteins in 69 species: Archae - 0; Bacteria - 125; Metazoa - 0; Fungi - 0; Plants - 111; Viruses - 0; Other Eukaryotes - 8 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

23090944..23091580

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116106.3 → NP_191800.1 CP12 domain-containing protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191800.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LC81, Q9LZP9

UniProtKB/TrEMBL

A0A178VHQ2, A0A654FK17

Conserved Domains (1) summary

PLN00204
Location:1 → 131

PLN00204; CP12 gene family protein; Provisional