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Transketolase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825246, updated on 18-Sep-2024

Summary

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Official Full Name
Transketolase
Primary source
TAIR:AT3G60750
Locus tag
AT3G60750
See related
Araport:AT3G60750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtTKL1; TKL1; transketolase 1
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Genomic context

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Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (22453668..22457458)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plasmodesmata-located protein 8 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S13/S15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of plastid transketolase in tobacco results in a thiamine auxotrophic phenotype. Khozaei M, et al. Plant Cell, 2015 Feb. PMID 25670766, Free PMC Article
  2. Phosphorylation of Arabidopsis transketolase at Ser428 provides a potential paradigm for the metabolic control of chloroplast carbon metabolism. Rocha AG, et al. Biochem J, 2014 Mar 1. PMID 24328790, Free PMC Article
  3. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
  4. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230
  5. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results reveal the crucial importance of the level of transketolase activity to provide the precursor for synthesis of intermediates and to enable plants to produce thiamine and thiamine pyrophosphate for growth and development.
    Title: Overexpression of plastid transketolase in tobacco results in a thiamine auxotrophic phenotype.
  2. Results of the present study point to a role for transketolase (TKL) phosphorylation in the regulation of carbon allocation.
    Title: Phosphorylation of Arabidopsis transketolase at Ser428 provides a potential paradigm for the metabolic control of chloroplast carbon metabolism.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001203216.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transketolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transketolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in reductive pentose-phosphate cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
is_active_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
is_active_in chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
Transketolase
NP_001190145.1
  • Transketolase; FUNCTIONS IN: catalytic activity, transketolase activity; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Transketolase, N-terminal (InterPro:IPR005474), Transketolase, C-terminal (InterPro:IPR005476), Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (InterPro:IPR009014), Transketolase-like, pyrimidine-binding domain (InterPro:IPR005475), Transketolase binding site (InterPro:IPR020826), Transketolase, bacterial-like (InterPro:IPR005478), Transketolase-like, C-terminal (InterPro:IPR015941); BEST Arabidopsis thaliana protein match is: Transketolase (TAIR:AT2G45290.1).
NP_567103.1
  • Transketolase; FUNCTIONS IN: catalytic activity, transketolase activity; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Transketolase, bacterial-like (InterPro:IPR005478), Transketolase, N-terminal (InterPro:IPR005474), Transketolase, C-terminal (InterPro:IPR005476), Transketolase-like, C-terminal (InterPro:IPR015941), Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (InterPro:IPR009014), Transketolase-like, pyrimidine-binding domain (InterPro:IPR005475), Transketolase binding site (InterPro:IPR020826); BEST Arabidopsis thaliana protein match is: Transketolase (TAIR:AT2G45290.1); Has 19296 Blast hits to 19203 proteins in 2759 species: Archae - 202; Bacteria - 11440; Metazoa - 321; Fungi - 314; Plants - 204; Viruses - 0; Other Eukaryotes - 6815 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22453668..22457458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115939.3 → NP_567103.1  Transketolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567103.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGH8, Q84WI5, Q8LE99, Q8RWV0, Q944P9, Q9LZY8
    UniProtKB/TrEMBL
    A0A178VEI0, A0A5S9XPC9
    Conserved Domains (1) summary
    PLN02790
    Location:88 → 740
    PLN02790; transketolase

  2. NM_001203216.2 → NP_001190145.1  Transketolase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190145.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4JBY2
    Conserved Domains (4) summary
    cd07033
    Location:434 → 597
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PLN02790
    Location:88 → 739
    PLN02790; transketolase
    pfam00456
    Location:83 → 413
    Transketolase_N; Transketolase, thiamine diphosphate binding domain
    pfam02780
    Location:627 → 732
    Transketolase_C; Transketolase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RWV0.1

Gene LinkOut

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