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VAP27-1 vesicle associated protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825231, updated on 18-Sep-2024

Summary

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Official Symbol
VAP27-1
Official Full Name
vesicle associated protein
Primary source
TAIR:AT3G60600
Locus tag
AT3G60600
See related
Araport:AT3G60600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
(AT)VAP; VAMP/SYNAPTOBREVIN-ASSOCIATED PROTEIN 27-1; VAP; VAP27; vesicle associated protein
Summary
Encodes VAP27 (for Vesicle-Associated Protein). VAP27 has high homology to the VAP33 family of SNARE-like proteins from animals. May be involved in vesicular transport to or from the ER. Located exclusively in limiting membrane of protein storage vacuoles. Binds SRC2.
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Genomic context

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See VAP27-1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Sequence:
Chromosome: 3; NC_003074.8 (22400110..22402724)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene C2H2-like zinc finger protein Neighboring gene ncRNA Neighboring gene cytochrome P450 family protein Neighboring gene miscRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The VAMP-associated protein VAP27-1 plays a crucial role in plant resistance to ER stress by modulating ER-PM contact architecture in Arabidopsis. Man Y, et al. Plant Commun, 2024 Jul 8. PMID 38678366, Free PMC Article
  2. ER-associated VAP27-1 and VAP27-3 proteins functionally link the lipid-binding ORP2A at the ER-chloroplast contact sites. Renna L, et al. Nat Commun, 2024 Jul 17. PMID 39019917, Free PMC Article
  3. Plant VAP27 proteins: domain characterization, intracellular localization and role in plant development. Wang P, et al. New Phytol, 2016 Jun. PMID 27159525
  4. The SNARE protein Syp71 is essential for turnip mosaic virus infection by mediating fusion of virus-induced vesicles with chloroplasts. Wei T, et al. PLoS Pathog, 2013. PMID 23696741, Free PMC Article
  5. Characterization of plant proteins that interact with cowpea mosaic virus '60K' protein in the yeast two-hybrid system. Carette JE, et al. J Gen Virol, 2002 Apr. PMID 11907339

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ER-associated VAP27-1 and VAP27-3 proteins functionally link the lipid-binding ORP2A at the ER-chloroplast contact sites.
    Title: ER-associated VAP27-1 and VAP27-3 proteins functionally link the lipid-binding ORP2A at the ER-chloroplast contact sites.
  2. The VAMP-associated protein VAP27-1 plays a crucial role in plant resistance to ER stress by modulating ER-PM contact architecture in Arabidopsis.
    Title: The VAMP-associated protein VAP27-1 plays a crucial role in plant resistance to ER stress by modulating ER-PM contact architecture in Arabidopsis.
  3. SEIPIN Isoforms Interact with the Membrane-Tethering Protein VAP27-1 for Lipid Droplet Formation.
    Title: SEIPIN Isoforms Interact with the Membrane-Tethering Protein VAP27-1 for Lipid Droplet Formation.
  4. VAP27-proteins bridge the endoplasmic reticulum with endocytic membranes and maintain endocytic traffic, likely through their interaction with clathrin.
    Title: Plant Endocytosis Requires the ER Membrane-Anchored Proteins VAP27-1 and VAP27-3.
  5. VAP27 proteins used at ER/PM contact sites (EPCSs) are essential for normal endoplasmic reticulum (ER)-cytoskeleton interaction and for plant development.
    Title: Plant VAP27 proteins: domain characterization, intracellular localization and role in plant development.
  6. NET3C and VAP27 localize to puncta at the PM and also form homodimers/oligomers, and together form complexes with actin and microtubules. F-actin modulates the turnover of NET3C and microtubules regulate the exchange of VAP27 at these puncta.
    Title: The plant cytoskeleton, NET3C, and VAP27 mediate the link between the plasma membrane and endoplasmic reticulum.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001035826.1
NM_001035827.1
NM_115924.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
located_in protein storage vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
vesicle associated protein
NP_001030903.1
  • VAMP/SYNAPTOBREVIN-ASSOCIATED PROTEIN 27-1 (VAP27-1); FUNCTIONS IN: protein binding; INVOLVED IN: intracellular transport; LOCATED IN: in 7 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: PapD-like (InterPro:IPR008962), Major sperm protein (InterPro:IPR000535), Vesicle-associated membrane protein (InterPro:IPR016763); BEST Arabidopsis thaliana protein match is: plant VAP homolog 12 (TAIR:AT2G45140.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001030904.1
  • VAMP/SYNAPTOBREVIN-ASSOCIATED PROTEIN 27-1 (VAP27-1); FUNCTIONS IN: protein binding; INVOLVED IN: intracellular transport; LOCATED IN: in 7 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: PapD-like (InterPro:IPR008962), Major sperm protein (InterPro:IPR000535), Vesicle-associated membrane protein (InterPro:IPR016763); BEST Arabidopsis thaliana protein match is: plant VAP homolog 12 (TAIR:AT2G45140.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_567101.1
  • vesicle associated protein (VAP); FUNCTIONS IN: protein binding; INVOLVED IN: intracellular transport; LOCATED IN: in 7 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: PapD-like (InterPro:IPR008962), Major sperm protein (InterPro:IPR000535), Vesicle-associated membrane protein (InterPro:IPR016763); BEST Arabidopsis thaliana protein match is: plant VAP homolog 12 (TAIR:AT2G45140.1); Has 1108 Blast hits to 1074 proteins in 204 species: Archae - 0; Bacteria - 0; Metazoa - 446; Fungi - 141; Plants - 434; Viruses - 0; Other Eukaryotes - 87 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22400110..22402724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115924.4 → NP_567101.1  vesicle associated protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567101.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHW7, Q2V3M6, Q2V3M7, Q8LDM1, Q8VZ95, Q9M003
    UniProtKB/TrEMBL
    A0A178VEY8, A0A5S9XMU5
    Conserved Domains (1) summary
    pfam00635
    Location:22 → 129
    Motile_Sperm; MSP (Major sperm protein) domain

  2. NM_001035827.1 → NP_001030904.1  vesicle associated protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030904.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VZ95
    Conserved Domains (1) summary
    pfam00635
    Location:22 → 129
    Motile_Sperm; MSP (Major sperm protein) domain

  3. NM_001035826.1 → NP_001030903.1  vesicle associated protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030903.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VZ95
    Conserved Domains (1) summary
    pfam00635
    Location:22 → 129
    Motile_Sperm; MSP (Major sperm protein) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VZ95.1

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