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FKBP-like peptidyl-prolyl cis-trans isomerase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 825208, updated on 18-Sep-2024

Summary

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Official Full Name
FKBP-like peptidyl-prolyl cis-trans isomerase family protein
Primary source
TAIR:AT3G60370
Locus tag
AT3G60370
See related
Araport:AT3G60370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Summary
Encodes an immunophilin, FKBP20-2, that belongs to the FK-506 binding protein (FKBP) subfamily functioning as peptidyl-prolyl isomerases (PPIases) in protein folding. FKBP20-2 has a unique pair of cysteines at the C terminus and was found to be reduced by thioredoxin (Trx) (itself reduced by NADPH by means of NADP-Trx reductase). The FKBP20-2 protein, which contains only two of the five amino acids required for catalysis, showed a low level of PPIase activity that was unaffected on reduction by Trx. Genetic disruption of the FKBP20-2 gene provide evidence that FKBP20-2 participates specifically in the accumulation of the PSII supercomplex in the chloroplast thylakoid lumen by means of a mechanism that has yet to be determined.
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Genomic context

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Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (22314637..22316625, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ARABIDILLO-2 Neighboring gene embryo sac development arrest 14 Neighboring gene cotton fiber protein Neighboring gene homeobox-leucine zipper protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana. Lima A, et al. Proc Natl Acad Sci U S A, 2006 Aug 15. PMID 16894144, Free PMC Article
  2. Identification of potential targets for thylakoid oxidoreductase AtVKOR/LTO1 in chloroplasts. Lu Y, et al. Protein Pept Lett, 2014. PMID 25412899
  3. Proteome map of the chloroplast lumen of Arabidopsis thaliana. Schubert M, et al. J Biol Chem, 2002 Mar 8. PMID 11719511
  4. Central functions of the lumenal and peripheral thylakoid proteome of Arabidopsis determined by experimentation and genome-wide prediction. Peltier JB, et al. Plant Cell, 2002 Jan. PMID 11826309, Free PMC Article
  5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FKBP20-2 is an immunophilin of the chloroplast thylakoid lumen and is required for accumulation of the PSII supercomplex in Arabidopsis thaliana [FKBP20-2].
    Title: A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001340042.1
NM_115901.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within photosystem II assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast thylakoid lumen HDA PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in thylakoid HDA PubMed 
located_in thylakoid lumen HDA PubMed 

General protein information

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Preferred Names
FKBP-like peptidyl-prolyl cis-trans isomerase family protein
NP_567098.2
  • FKBP-like peptidyl-prolyl cis-trans isomerase family protein; FUNCTIONS IN: FK506 binding, oxidoreductase activity, peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: photosystem II assembly; LOCATED IN: thylakoid, thylakoid lumen, chloroplast thylakoid lumen, chloroplast; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT4G19830.1); Has 7131 Blast hits to 6812 proteins in 1455 species: Archae - 6; Bacteria - 3821; Metazoa - 1227; Fungi - 400; Plants - 644; Viruses - 0; Other Eukaryotes - 1033 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    22314637..22316625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115901.4 → NP_567098.2  FKBP-like peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567098.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WRJ7, Q9M222
    UniProtKB/TrEMBL
    A0A178VFC2
    Conserved Domains (1) summary
    pfam00254
    Location:134 → 222
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. NM_001340042.1 → NP_001327191.1  FKBP-like peptidyl-prolyl cis-trans isomerase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VFC2, A0A1I9LRJ6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0WRJ7.1

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