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NAGK N-acetyl-l-glutamate kinase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824923, updated on 18-Sep-2024

Summary

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Official Symbol
NAGK
Official Full Name
N-acetyl-l-glutamate kinase
Primary source
TAIR:AT3G57560
Locus tag
AT3G57560
See related
Araport:AT3G57560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
N-acetyl-l-glutamate kinase
Summary
encodes a N-acetylglutamate kinase, involved in arginine biosynthesis
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Genomic context

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See NAGK in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_003074.8 (21310825..21312378, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Remorin family protein Neighboring gene guanylate kinase Neighboring gene ARM repeat superfamily protein Neighboring gene F-box and associated interaction domains-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana. Huang J, et al. J Integr Plant Biol, 2017 Sep. PMID 28294536
  2. A widespread glutamine-sensing mechanism in the plant kingdom. Chellamuthu VR, et al. Cell, 2014 Nov 20. PMID 25416954
  3. Metabolite regulation of the interaction between Arabidopsis thaliana PII and N-acetyl-l-glutamate kinase. Feria Bourrellier AB, et al. Biochem Biophys Res Commun, 2009 Oct 2. PMID 19631611
  4. N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control. Beez S, et al. J Mol Biol, 2009 Jun 19. PMID 19409905
  5. Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana. Mizuno Y, et al. J Biol Chem, 2007 Dec 7. PMID 17913711

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. functions with arginine to regulate gametophyte function and embryo development
    Title: Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana.
  2. These results reveal a complex metabolic control of the PII interaction with NAGK in the chloroplast stroma of higher plants.
    Title: Metabolite regulation of the interaction between Arabidopsis thaliana PII and N-acetyl-l-glutamate kinase.
  3. Data show that the non-conserved C-terminus of Synechococcus elongatus N-acetylglutamate kinase (NAGK) enhances arginine inhibition and holds most of the differences between S. elongatus and Arabidopsis NAGK with respect to arginine sensitivity.
    Title: N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_115616.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables acetylglutamate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within arginine biosynthetic process via ornithine TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast thylakoid HDA PubMed 
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
N-acetyl-l-glutamate kinase
NP_191315.1
  • N-acetyl-l-glutamate kinase (NAGK); FUNCTIONS IN: acetylglutamate kinase activity; INVOLVED IN: arginine biosynthetic process via ornithine, arginine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: N-acetylglutamate kinase (InterPro:IPR011148), Glutamate 5-kinase (InterPro:IPR001057), Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Acetylglutamate kinase (InterPro:IPR004662); BEST Arabidopsis thaliana protein match is: N-acetyl-l-glutamate synthase 2 (TAIR:AT4G37670.2); Has 9387 Blast hits to 9387 proteins in 2227 species: Archae - 281; Bacteria - 6131; Metazoa - 9; Fungi - 140; Plants - 140; Viruses - 0; Other Eukaryotes - 2686 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    21310825..21312378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115616.3 → NP_191315.1  N-acetyl-l-glutamate kinase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191315.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LA25, Q9SCL7
    UniProtKB/TrEMBL
    A0A178V7F4, A0A5S9XLX7, A0A654FIN6
    Conserved Domains (1) summary
    PLN02512
    Location:39 → 347
    PLN02512; acetylglutamate kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SCL7.1

Gene LinkOut

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