EIF3E eukaryotic translation initiation factor 3E [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: EIF3E
Official Full Name: eukaryotic translation initiation factor 3E
Primary source: TAIR:AT3G57290
Locus tag: AT3G57290
See related: Araport:AT3G57290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATEIF3E-1; ATINT6; eukaryotic translation initiation factor 3E; INT-6; INT6; TIF3E1
Summary: Encodes a protein that is found in not only the eif3 complex but also in association with subunits of the COP9 signalosome. eIF3e appears to be subjected to proteasome-dependent degradation that requires the PCI domain of eIF3e. The level of eIF3e present in cells appears to affect the rate of translation.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See EIF3E in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 8

Sequence:: Chromosome: 3; NC_003074.8 (21196517..21199319, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study concludes that the COP9 signalosome maintains a precise regulation of eIF3e levels, which is necessary for normal development in Arabidopsis
Title: Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_115589.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation repressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription initiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
part_of cytosolic proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: eukaryotic translation initiation factor 3E

NP_567047.1

eukaryotic translation initiation factor 3E (EIF3E); FUNCTIONS IN: protein binding, translation initiation factor activity; INVOLVED IN: flower development, response to salt stress, translation, photomorphogenesis, transcription initiation; LOCATED IN: signalosome, eukaryotic translation initiation factor 3 complex, nucleus, plasma membrane, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Translation initiation factor 3, subunit 6, eukaryotic (InterPro:IPR016650), Proteasome component (PCI) domain (InterPro:IPR000717), Eukaryotic translation initiation factor 3 (eIF3), subunit 6, N-terminal (InterPro:IPR019010); Has 641 Blast hits to 638 proteins in 243 species: Archae - 0; Bacteria - 2; Metazoa - 287; Fungi - 119; Plants - 138; Viruses - 0; Other Eukaryotes - 95 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

21196517..21199319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115589.5 → NP_567047.1 eukaryotic translation initiation factor 3E [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567047.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C5Z3, Q9M2L8, Q9M4T7

UniProtKB/TrEMBL

A0A178VL03, A0A5S9XMA6

Conserved Domains (1) summary

cd21378
Location:7 → 433

eIF3E; eukaryotic translation initiation factor 3 subunit E