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NAP57 homologue of NAP57 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824882, updated on 18-Sep-2024

Summary

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Official Symbol
NAP57
Official Full Name
homologue of NAP57
Primary source
TAIR:AT3G57150
Locus tag
AT3G57150
See related
Araport:AT3G57150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtCBF5; AtNAP57; CBF5; homologue of NAP57
Summary
Encodes a putative pseudouridine synthase (NAP57).
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Genomic context

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See NAP57 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_003074.8 (21153815..21156075, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein / BTB/POZ domain-containing protein Neighboring gene sugar-dependent 1-like protein Neighboring gene ncRNA Neighboring gene cysteine-rich TM module stress tolerance protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of Arabidopsis thaliana AtNAP57--a homologue of yeast pseudouridine synthase Cbf5p. Maceluch J, et al. Acta Biochim Pol, 2001. PMID 11833778
  2. Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly. Song J, et al. Nucleic Acids Res, 2021 Sep 20. PMID 34403479, Free PMC Article
  3. Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1. Lermontova I, et al. Plant Mol Biol, 2007 Nov. PMID 17712600
  4. Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance. Kannan K, et al. Mol Cell Biol, 2008 Apr. PMID 18212040, Free PMC Article
  5. Mutations in SUPPRESSOR OF VARIEGATION1, a factor required for normal chloroplast translation, suppress var2-mediated leaf variegation in Arabidopsis. Yu F, et al. Plant Cell, 2008 Jul. PMID 18599582, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly.
    Title: Arabidopsis retains vertebrate-type telomerase accessory proteins via a plant-specific assembly.
  2. AtNAP57 is a conserved component of the telomerase RNP in multicellular organisms that is required for telomere maintenance. [AtNAP57]
    Title: Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.
  3. T66A NAP57 behaves as a dominant-negative inhibitor of telomerase. dyskerin is a conserved component of the telomerase RNP complex in higher eukaryotes that is required for maximal enzyme activity in vivo.
    Title: Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.
  4. [CBF5] Arabidopsis CBF5 interacts with NAF1 in planta.
    Title: Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_115574.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables pseudouridine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables pseudouridine synthase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
homologue of NAP57
NP_191274.1
  • homologue of NAP57 (NAP57); FUNCTIONS IN: pseudouridine synthase activity; INVOLVED IN: pseudouridine synthesis, RNA modification, RNA processing; LOCATED IN: cytosol, nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pseudouridine synthase, catalytic domain (InterPro:IPR020103), Pseudouridine synthase/archaeosine transglycosylase-like (InterPro:IPR015947), Pseudouridine synthase/archaeosine transglycosylase (InterPro:IPR002478), H/ACA ribonucleoprotein complex, subunit Cbf5 (InterPro:IPR004802), Pseudouridine synthase II, TruB, N-terminal (InterPro:IPR002501), Dyskerin-like (InterPro:IPR012960), Uncharacterised domain 2 (InterPro:IPR004521); BEST Arabidopsis thaliana protein match is: Pseudouridine synthase family protein (TAIR:AT5G14460.1); Has 114172 Blast hits to 55339 proteins in 3754 species: Archae - 551; Bacteria - 17094; Metazoa - 41477; Fungi - 11530; Plants - 5704; Viruses - 752; Other Eukaryotes - 37064 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    21153815..21156075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115574.3 → NP_191274.1  homologue of NAP57 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42348, Q94AA2, Q9LD90
    UniProtKB/TrEMBL
    A0A178VJL1, A0A384LF80, A0A5S9XLR1, C0SVF3
    Conserved Domains (1) summary
    TIGR00425
    Location:47 → 372
    CBF5; rRNA pseudouridine synthase, putative
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LD90.1

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