SIP2;1 small and basic intrinsic protein 2;1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SIP2;1
Official Full Name: small and basic intrinsic protein 2;1
Primary source: TAIR:AT3G56950
Locus tag: AT3G56950
See related: Araport:AT3G56950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: SIP2; SMALL AND BASIC INTRINSIC PROTEIN 2; small and basic intrinsic protein 2;1; T8M16.9
Summary: One of the Major Intrinsic Proteins(MIPs) which facilitate the passive transport of small molecules across membranes.Belongs to a family of plant aquaporins.Similar to yeast and radish aquaporins. Located on ER.
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Genomic context

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See SIP2;1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (21078297..21079925, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIP2;1 are the small aquaporins. They are localized in ER of all tissues except dry seeds. They do not show water channel activity but may act as ER channel for small molecules or ions. [SIP2;1]
Title: Novel type aquaporin SIPs are mainly localized to the ER membrane and show cell-specific expression in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_115554.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within pollen germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: small and basic intrinsic protein 2;1

NP_001190113.1

small and basic intrinsic protein 2;1 (SIP2;1); FUNCTIONS IN: transporter activity; INVOLVED IN: transport; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: Aquaporin-like superfamily protein (TAIR:AT5G18290.2).

NP_191254.1

small and basic intrinsic protein 2;1 (SIP2;1); FUNCTIONS IN: transporter activity; INVOLVED IN: transport; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: Aquaporin-like superfamily protein (TAIR:AT5G18290.2); Has 1253 Blast hits to 1253 proteins in 361 species: Archae - 9; Bacteria - 357; Metazoa - 222; Fungi - 102; Plants - 511; Viruses - 0; Other Eukaryotes - 52 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

21078297..21079925 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203184.1 → NP_001190113.1 small and basic intrinsic protein 2;1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190113.1

Status: REVIEWED

UniProtKB/TrEMBL

F4J0V0

Conserved Domains (1) summary

cl00200
Location:12 → 218

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_115554.4 → NP_191254.1 small and basic intrinsic protein 2;1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191254.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M1K3

UniProtKB/TrEMBL

A0A178VEI5, A0A5S9XLL1

Conserved Domains (1) summary

cl00200
Location:12 → 218

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...