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ROC2 rotamase cyclophilin 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824773, updated on 18-Sep-2024

Summary

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Official Symbol
ROC2
Official Full Name
rotamase cyclophilin 2
Primary source
TAIR:AT3G56070
Locus tag
AT3G56070
See related
Araport:AT3G56070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
rotamase cyclophilin 2; ROTAMASE CYCLOPHILIN 2; ROTAMASE CYP 2
Summary
rotamase cyclophilin 2 (ROC2) exhibiting peptidyl-prolyl cis-trans isomerase activity involved in signal transduction.
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Genomic context

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See ROC2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_003074.8 (20806566..20808168, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Protein kinase family protein Neighboring gene Glucose-methanol-choline (GMC) oxidoreductase family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene tRNA-Lys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. Kaur G, et al. PLoS One, 2015. PMID 26317213, Free PMC Article
  2. Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. Kovalev N, et al. J Virol, 2013 Dec. PMID 24089553, Free PMC Article
  3. Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins. Chou IT, et al. Plant Mol Biol, 1997 Dec. PMID 9426607
  4. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
  5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roc1, and Roc2 binds to the Tomato bushy stunt tombusvirus RNA and replication proteins, resulting in inhibition of virus repication.
    Title: Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001339763.1
NM_115465.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cyclosporin A binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
rotamase cyclophilin 2
NP_001319764.1
  • rotamase cyclophilin 2 (ROC2); CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 3 (TAIR:AT2G16600.1); Has 16518 Blast hits to 16486 proteins in 2631 species: Archae - 108; Bacteria - 6748; Metazoa - 2914; Fungi - 1377; Plants - 1262; Viruses - 4; Other Eukaryotes - 4105 (source: NCBI BLink).
NP_191166.1
  • rotamase cyclophilin 2 (ROC2); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity, cyclosporin A binding; INVOLVED IN: protein folding, response to cadmium ion, signal transduction; LOCATED IN: cytosol; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 3 (TAIR:AT2G16600.1); Has 16518 Blast hits to 16486 proteins in 2631 species: Archae - 108; Bacteria - 6748; Metazoa - 2914; Fungi - 1377; Plants - 1262; Viruses - 4; Other Eukaryotes - 4105 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20806566..20808168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115465.5 → NP_191166.1  rotamase cyclophilin 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_191166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38867, Q38901, Q9LYN4
    UniProtKB/TrEMBL
    A0A178VE97, A0A5S9XL84
    Conserved Domains (1) summary
    cd01926
    Location:4 → 169
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

  2. NM_001339763.1 → NP_001319764.1  rotamase cyclophilin 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38867, Q38901, Q9LYN4
    UniProtKB/TrEMBL
    A0A178VE97, A0A5S9XL84
    Conserved Domains (1) summary
    cd01926
    Location:4 → 169
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q38867.2

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