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LAF3 Amidohydrolase family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824751, updated on 18-Sep-2024

Summary

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Official Symbol
LAF3
Official Full Name
Amidohydrolase family
Primary source
TAIR:AT3G55850
Locus tag
AT3G55850
See related
Araport:AT3G55850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
LAF3 ISF1; LAF3 ISF2; LAF3 ISOFORM 2; LONG AFTER FAR-RED 3; LONG AFTER FAR-RED 3 ISOFORM 1
Summary
Encodes a product that might regulate nucleo-cytoplasmic trafficking of an intermediate(s) involved in phyA signal transduction. Differs from isoform 2 only in the first few N-terminal amino acids.
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Genomic context

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See LAF3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Sequence:
Chromosome: 3; NC_003074.8 (20721602..20725893, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Fasciclin-like arabinogalactan family protein Neighboring gene Nucleotide-diphospho-sugar transferases superfamily protein Neighboring gene Hs1pro-1 protein Neighboring gene uncharacterized protein Neighboring gene ADC synthase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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NM_001339748.1
NM_001339749.1
NM_001339750.1
NM_001339751.1
NM_115443.4
NM_202716.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in de-etiolation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to far red light IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to far red light IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in seed germination IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Amidohydrolase family
NP_001319763.1
  • LONG AFTER FAR-RED 3 (LAF3); FUNCTIONS IN: hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; INVOLVED IN: biological_process unknown; LOCATED IN: perinuclear region of cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amidohydrolase 3 (InterPro:IPR013108), Metal-dependent hydrolase, composite domain (InterPro:IPR011059); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_567027.2
  • LAF3 ISOFORM 2 (LAF3 ISF2); FUNCTIONS IN: hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; INVOLVED IN: biological_process unknown; LOCATED IN: perinuclear region of cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amidohydrolase 3 (InterPro:IPR013108), Metal-dependent hydrolase, composite domain (InterPro:IPR011059); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20721602..20725893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001339748.1 → NP_001319763.1  Amidohydrolase family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2EX26, F4IY41
    Conserved Domains (2) summary
    cd01300
    Location:1 → 432
    YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
    cl00281
    Location:406 → 460
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  2. NM_001339750.1 → NP_001326018.1  Amidohydrolase family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LN02
    Conserved Domains (2) summary
    cd01300
    Location:9 → 415
    YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
    cl00281
    Location:389 → 443
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  3. NM_001339749.1 → NP_001326016.1  Amidohydrolase family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LMZ9

  4. NM_202716.3 → NP_974445.2  Amidohydrolase family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974445.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1I9LN01, F4IY42, Q7Y048, Q7Y049, Q93ZE1, Q9LY60
    UniProtKB/TrEMBL
    A0A7G2EX26
    Conserved Domains (2) summary
    cd01300
    Location:71 → 554
    YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
    cl00281
    Location:528 → 582
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  5. NM_115443.4 → NP_567027.2  Amidohydrolase family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567027.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XLA5
    Conserved Domains (2) summary
    cd01300
    Location:64 → 547
    YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
    cl00281
    Location:521 → 575
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  6. NM_001339751.1 → NP_001326017.1  Amidohydrolase family [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XLA5
    Conserved Domains (2) summary
    cd01300
    Location:64 → 547
    YtcJ_like; YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling.
    cl00281
    Location:521 → 575
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1I9LN01.1

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