U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MKP1 mitogen-activated protein kinase phosphatase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824693, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
MKP1
Official Full Name
mitogen-activated protein kinase phosphatase 1
Primary source
TAIR:AT3G55270
Locus tag
AT3G55270
See related
Araport:AT3G55270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE 1; ATMKP1; mitogen-activated protein kinase phosphatase 1
Summary
Encodes MAP kinase phosphatase 1 (MKP1). Loss of MKP1 results in hypersensitivity to acute UV-B stress, but without impairing UV-B acclimation.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MKP1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (20496081..20500019)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene beta-hexosaminidase 1 Neighboring gene ribosomal protein L23AB Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of MAPK phosphatase 1 (AtMKP1) by calmodulin in Arabidopsis. Lee K, et al. J Biol Chem, 2008 Aug 29. PMID 18579522, Free PMC Article
  2. MKP1 acts as a key modulator of stomatal development. Jangra R, et al. Plant Signal Behav, 2019. PMID 30983545, Free PMC Article
  3. Mitogen-Activated Protein Kinase Phosphatase 1 (MKP1) Negatively Regulates the Production of Reactive Oxygen Species During Arabidopsis Immune Responses. Escudero V, et al. Mol Plant Microbe Interact, 2019 Apr. PMID 30387369
  4. MAP KINASE PHOSPHATASE1 Controls Cell Fate Transition during Stomatal Development. Tamnanloo F, et al. Plant Physiol, 2018 Sep. PMID 30002258, Free PMC Article
  5. Phosphorylation of Arabidopsis MAP Kinase Phosphatase 1 (MKP1) Is Required for PAMP Responses and Resistance against Bacteria. Jiang L, et al. Plant Physiol, 2017 Dec. PMID 29070514, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis.
    Title: Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis.
  2. An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.
    Title: An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.
  3. MKP1 plays an important role at the early stage of stomatal development for the cell fate transition leading to stomatal differentiation.
    Title: MKP1 acts as a key modulator of stomatal development.
  4. MKP1 functions downstream of the heterotrimeric G protein during MAMP-triggered immunity, directly regulating the activity of RBOHD and ROS production as well as other immune responses.
    Title: Mitogen-Activated Protein Kinase Phosphatase 1 (MKP1) Negatively Regulates the Production of Reactive Oxygen Species During Arabidopsis Immune Responses.
  5. Data indicate the important role of MAP KINASE PHOSPHATASE1 (MKP1) in controlling MAPK signaling specificity and cell fate decision during stomatal development.
    Title: MAP KINASE PHOSPHATASE1 Controls Cell Fate Transition during Stomatal Development.
  6. These results provide insight into the roles of phosphorylation in the regulation of MKP1 during pathogen-associated molecular pattern signaling and resistance to bacteria.
    Title: Phosphorylation of Arabidopsis MAP Kinase Phosphatase 1 (MKP1) Is Required for PAMP Responses and Resistance against Bacteria.
  7. These data highlight MPK6 and MKP1 as components of an L-Glutamate pathway linking the auxin response, and cell division for primary root growth.
    Title: Mitogen activated protein kinase 6 and MAP kinase phosphatase 1 are involved in the response of Arabidopsis roots to L-glutamate.
  8. MKP1 role in ultraviolet induced stomatal closure
    Title: Mitogen-Activated Protein Kinase Phosphatases Affect UV-B-Induced Stomatal Closure via Controlling NO in Guard Cells.
  9. This study pinpoints the specificity of MAPK regulation by the different MAPK phosphatases AP2C1 and MKP1, which control the same MAPK substrates, nevertheless leading to different downstream events.
    Title: Protein phosphatase AP2C1 negatively regulates basal resistance and defense responses to Pseudomonas syringae.
  10. These results identify MKP1 as a protein dually targeted to cytosol and peroxisomes.
    Title: MAP kinase phosphatase 1 harbors a novel PTS1 and is targeted to peroxisomes following stress treatments.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_115385.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to L-glutamate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV-B IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV-C IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase phosphatase 1
NP_567018.5
  • mitogen-activated protein kinase phosphatase 1 (MKP1); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: MAPK phosphatase 2 (TAIR:AT3G06110.3); Has 4115 Blast hits to 4050 proteins in 297 species: Archae - 2; Bacteria - 48; Metazoa - 2335; Fungi - 439; Plants - 312; Viruses - 98; Other Eukaryotes - 881 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20496081..20500019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115385.7 → NP_567018.5  mitogen-activated protein kinase phosphatase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q940K2, Q9C5S1, Q9M3C4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools