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SAP130a Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824686, updated on 18-Sep-2024

Summary

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Official Symbol
SAP130a
Official Full Name
Cleavage and polyadenylation specificity factor (CPSF) A subunit protein
Primary source
TAIR:AT3G55200
Locus tag
AT3G55200
See related
Araport:AT3G55200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana spliceosome-associated protein 130 a; AtSAP130a; spliceosome-associated protein 130 a
Summary
Encodes a spliceosomal protein that is required for proper reproduction. RNAi lines display low pollen viability,caused by a defect in the transition from microspore to bicellular stage during pollen development.
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Genomic context

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See SAP130a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (20460329..20465201)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene NAC domain containing protein 63 Neighboring gene Cleavage and polyadenylation specificity factor (CPSF) A subunit protein Neighboring gene Disease resistance-responsive (dirigent-like protein) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtSAP130/AtSF3b-3 function is required for reproduction in Arabidopsis thaliana. Aki S, et al. Plant Cell Physiol, 2011 Aug. PMID 21680607
  2. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
  3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtSAP130a and AtSAP130b play an indispensable role in specific spatiotemporal events in reproduction.[AtSAp130a]
    Title: AtSAP130/AtSF3b-3 function is required for reproduction in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001339727.1
NM_001339728.1

Gene Ontology Provided by TAIR

Process Evidence Code Pubs
involved_in microgametogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant ovule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plant ovule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pollen germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Cleavage and polyadenylation specificity factor (CPSF) A subunit protein
NP_001319757.1
  • Cleavage and polyadenylation specificity factor (CPSF) A subunit protein; FUNCTIONS IN: nucleic acid binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: guard cell; CONTAINS InterPro DOMAIN/s: WD40 repeat (InterPro:IPR001680), Cleavage/polyadenylation specificity factor, A subunit, C-terminal (InterPro:IPR004871); BEST Arabidopsis thaliana protein match is: Cleavage and polyadenylation specificity factor (CPSF) A subunit protein (TAIR:AT3G55220.1); Has 1074 Blast hits to 953 proteins in 223 species: Archae - 0; Bacteria - 2; Metazoa - 406; Fungi - 248; Plants - 228; Viruses - 0; Other Eukaryotes - 190 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20460329..20465201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115378.4 → NP_567015.1  Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567015.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0DKL4, P0DKL6, Q570A5, Q9LD60
    UniProtKB/TrEMBL
    A0A178VN71, A0A5S9XL36, A0A654FFY1
    Conserved Domains (3) summary
    pfam03178
    Location:861 → 1180
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:75 → 589
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    cl29593
    Location:581 → 651
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001339727.1 → NP_001319757.1  Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0DKL4, P0DKL6, Q570A5, Q9LD60
    UniProtKB/TrEMBL
    A0A178VN71, A0A5S9XL36, A0A654FFY1
    Conserved Domains (3) summary
    pfam03178
    Location:861 → 1180
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:75 → 589
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    cl29593
    Location:581 → 651
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001339728.1 → NP_001327611.1  Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0DKL4, P0DKL6, Q570A5, Q9LD60
    UniProtKB/TrEMBL
    A0A178VN71, A0A5S9XL36, A0A654FFY1
    Conserved Domains (3) summary
    pfam03178
    Location:861 → 1180
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:75 → 589
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    cl29593
    Location:581 → 651
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DKL4.1
P0DKL6.1

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