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TON1A tonneau family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824665, updated on 18-Sep-2024

Summary

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Official Symbol
TON1A
Official Full Name
tonneau family protein
Primary source
TAIR:AT3G55000
Locus tag
AT3G55000
See related
Araport:AT3G55000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T15C9.7; TON1; TONNEAU 1; TONNEAU 1A
Summary
Encodes a protein of unknown function that is involved in cortical microtubule organization. Mutants exhibit abnormal cell growth and patterns of division. TON1A can functionally complement TON1B and their roles appear to be redundant in plants. Encodes a novel protein that is similar to human FOP and OFD1 centrosomal proteins. Localizes to the preprophase band, cytoplasm and cell cortex where it is probably associated with the cortical cytoskeleton. TON1A associates with plant centrins CEN1 and CEN2.
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Genomic context

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See TON1A in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Sequence:
Chromosome: 3; NC_003074.8 (20381460..20383878)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene tonneau 1b (TON1b) Neighboring gene phosphoribosylformylglycinamidine cyclo-ligase, chloroplast / phosphoribosyl-aminoimidazole synthetase / AIR synthase (PUR5)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana. Wu L, et al. Planta, 2024 Feb 8. PMID 38329545, Free PMC Article
  2. A protein phosphatase 2A complex spatially controls plant cell division. Spinner L, et al. Nat Commun, 2013. PMID 23673648
  3. The Arabidopsis TRM1-TON1 interaction reveals a recruitment network common to plant cortical microtubule arrays and eukaryotic centrosomes. Drevensek S, et al. Plant Cell, 2012 Jan. PMID 22286137, Free PMC Article
  4. Arabidopsis TONNEAU1 proteins are essential for preprophase band formation and interact with centrin. Azimzadeh J, et al. Plant Cell, 2008 Aug. PMID 18757558, Free PMC Article
  5. A tandem affinity purification-based technology platform to study the cell cycle interactome in Arabidopsis thaliana. Van Leene J, et al. Mol Cell Proteomics, 2007 Jul. PMID 17426018

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana.
    Title: TON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana.
  2. A protein complex that targets protein phosphatase 2A activity to microtubules, comprises TONNEAU1 and a PP2A heterotrimeric holoenzyme with FASS as regulatory subunit, is recruited to the cytoskeleton via the TONNEAU1-recruiting motif family of proteins.
    Title: A protein phosphatase 2A complex spatially controls plant cell division.
  3. Data show that TRM1 interacts in vivo with TON1 and is able to target TON1 to cortical microtubules via its C-terminal TON1 interaction motif.
    Title: The Arabidopsis TRM1-TON1 interaction reveals a recruitment network common to plant cortical microtubule arrays and eukaryotic centrosomes.
  4. Data show that TON1 protein associates with soluble and microsomal fractions of Arabidopsis cells, and are essential for preprophase band formation and interact with centrin.
    Title: Arabidopsis TONNEAU1 proteins are essential for preprophase band formation and interact with centrin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_115357.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cortical cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization NAS
Non-traceable Author Statement
more info
  
involved_in preprophase band assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in preprophase band IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tonneau family protein
NP_567012.1
  • TONNEAU 1A (TON1A); INVOLVED IN: microtubule cytoskeleton organization; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FGFR1 oncogene partner (FOP), N-terminal dimerisation domain (InterPro:IPR018993), LisH dimerisation motif (InterPro:IPR006594); BEST Arabidopsis thaliana protein match is: tonneau 1b (TON1b) (TAIR:AT3G55005.1); Has 229 Blast hits to 226 proteins in 73 species: Archae - 0; Bacteria - 3; Metazoa - 122; Fungi - 0; Plants - 65; Viruses - 0; Other Eukaryotes - 39 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20381460..20383878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115357.4 → NP_567012.1  tonneau family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567012.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FQ25
    UniProtKB/TrEMBL
    A0A654FH58, Q8LGF8
    Conserved Domains (2) summary
    pfam09398
    Location:61 → 137
    FOP_dimer; FOP N terminal dimerization domain
    pfam16045
    Location:77 → 104
    LisH_2; LisH
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FQ25.1

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