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VAMP727 vesicle-associated membrane protein 727 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824597, updated on 18-Sep-2024

Summary

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Official Symbol
VAMP727
Official Full Name
vesicle-associated membrane protein 727
Primary source
TAIR:AT3G54300
Locus tag
AT3G54300
See related
Araport:AT3G54300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATVAMP727; vesicle-associated membrane protein 727
Summary
Encodes a member of Synaptobrevin -like protein family. VAMP727 is a R-SNARE and interacts with SYP22/VTI11/SYP51. It is required for trafficking of storage proteins to the protein storage vacuoles (PSV) and also for PSV organization and biogenesis. Loss of function mutations have no phenotype but double mutants with SYP22 are embryo lethal.
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Genomic context

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See VAMP727 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (20108207..20110883, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ROOT GROWTH DEFECTIVE 3 Neighboring gene hemerythrin HHE cation-binding domain protein Neighboring gene DNA-directed RNA polymerase subunit alpha Neighboring gene Integrase-type DNA-binding superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SNARE proteins SYP22 and VAMP727 negatively regulate plant defense. Zhu XF, et al. Plant Signal Behav, 2019. PMID 31025584, Free PMC Article
  2. A SNARE complex unique to seed plants is required for protein storage vacuole biogenesis and seed development of Arabidopsis thaliana. Ebine K, et al. Plant Cell, 2008 Nov. PMID 18984676, Free PMC Article
  3. SYP22 and VAMP727 regulate BRI1 plasma membrane targeting to control plant growth in Arabidopsis. Zhang L, et al. New Phytol, 2019 Aug. PMID 30802967
  4. The Arabidopsis R-SNARE VAMP721 Interacts with KAT1 and KC1 K+ Channels to Moderate K+ Current at the Plasma Membrane. Zhang B, et al. Plant Cell, 2015 Jun. PMID 26002867, Free PMC Article
  5. The longin domain regulates subcellular targeting of VAMP7 in Arabidopsis thaliana. Uemura T, et al. FEBS Lett, 2005 May 23. PMID 15876431

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VAMP727-SYP22 SNARE complexes regulate plant defense might be via control of abundances of BRI1 on the plasma membrane.
    Title: SNARE proteins SYP22 and VAMP727 negatively regulate plant defense.
  2. Q-SNARE SYP22 and R-SNARE VAMP727 mediate the BRI trafficking to plasma membrane.
    Title: SYP22 and VAMP727 regulate BRI1 plasma membrane targeting to control plant growth in Arabidopsis.
  3. VAMP727 is a multicopy suppressor of SYP22, and helps mediate the fusion between the prevacuolar compartment and the vacuole.
    Title: A SNARE complex unique to seed plants is required for protein storage vacuole biogenesis and seed development of Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001084814.2
NM_001339657.1
NM_115290.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vacuole organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CORVET complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
vesicle-associated membrane protein 727
NP_001078283.1
  • vesicle-associated membrane protein 727 (VAMP727); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: vacuole organization, protein targeting to vacuole; LOCATED IN: endosome, SNARE complex, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Longin (InterPro:IPR010908), Longin-like (InterPro:IPR011012), Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: vesicle-associated membrane protein 726 (TAIR:AT1G04760.1); Has 2397 Blast hits to 2395 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 970; Fungi - 430; Plants - 618; Viruses - 0; Other Eukaryotes - 379 (source: NCBI BLink).
NP_190998.1
  • vesicle-associated membrane protein 727 (VAMP727); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: vacuole organization, protein targeting to vacuole; LOCATED IN: endosome, SNARE complex, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Longin (InterPro:IPR010908), Longin-like (InterPro:IPR011012), Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: vesicle-associated membrane protein 726 (TAIR:AT1G04760.1); Has 2397 Blast hits to 2395 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 970; Fungi - 430; Plants - 618; Viruses - 0; Other Eukaryotes - 379 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20108207..20110883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115290.5 → NP_190998.1  vesicle-associated membrane protein 727 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190998.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XE0, Q9M376
    UniProtKB/TrEMBL
    A0A178VIG0, A0A5S9XKU3
    Conserved Domains (2) summary
    cd14824
    Location:7 → 140
    Longin; longin domain
    pfam00957
    Location:146 → 234
    Synaptobrevin

  2. NM_001339657.1 → NP_001326058.1  vesicle-associated membrane protein 727 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XE0, Q9M376
    UniProtKB/TrEMBL
    A0A178VIG0, A0A5S9XKU3
    Conserved Domains (2) summary
    cd14824
    Location:7 → 140
    Longin; longin domain
    pfam00957
    Location:146 → 234
    Synaptobrevin

  3. NM_001084814.2 → NP_001078283.1  vesicle-associated membrane protein 727 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XE0, Q9M376
    UniProtKB/TrEMBL
    A0A178VIG0, A0A5S9XKU3
    Conserved Domains (2) summary
    cd14824
    Location:7 → 140
    Longin; longin domain
    pfam00957
    Location:146 → 234
    Synaptobrevin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M376.1

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