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PTR1 peptide transporter 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824581, updated on 18-Sep-2024

Summary

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Official Symbol
PTR1
Official Full Name
peptide transporter 1
Primary source
TAIR:AT3G54140
Locus tag
AT3G54140
See related
Araport:AT3G54140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA PEPTIDE TRANSPORTER 1; AtNPF8.1; ATPTR1; NPF8.1; NRT1/ PTR family 8.1; peptide transporter 1
Summary
Encodes a di- and tri-peptide transporter that recognizes a variety of different amino acid combinations. GFP-tagged PTR1 localizes to the plasma membrane and has 8 to 11 predicted transmembrane domains. PTR1 is expressed in a number of different vascular tissues throughout the plant based on promoter:GUS expression analysis. ptr1 mutants have a lower dry weight than wild type plants when both are grown with Pro-Ala or Ala-Ala dipeptides as their nitrogen source, suggesting that PTR1 plays a role in dipeptide uptake in the roots. Furthermore N content of ptr1 mutants is lower than that of wild type plants when grown with Pro-Ala or a mixture of dipeptides as nitrogen source
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Genomic context

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See PTR1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (20045603..20048745, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plant uncoupling mitochondrial protein 1 Neighboring gene Reticulon family protein Neighboring gene Josephin family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene RNI-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtPTR1, a plasma membrane peptide transporter expressed during seed germination and in vascular tissue of Arabidopsis. Dietrich D, et al. Plant J, 2004 Nov. PMID 15500465
  2. Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5. Hammes UZ, et al. J Biol Chem, 2010 Dec 17. PMID 20937801, Free PMC Article
  3. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
  4. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article
  5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5
    Title: Functional properties of the Arabidopsis peptide transporters AtPTR1 and AtPTR5.
  2. A new transporter mediating the uptake of di- and tripeptides was isolated from Arabidopsis thaliana. [AtPTR1]
    Title: AtPTR1, a plasma membrane peptide transporter expressed during seed germination and in vascular tissue of Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001339651.1
NM_115274.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptide transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables tripeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within dipeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within tripeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
peptide transporter 1
NP_190982.1
  • peptide transporter 1 (PTR1); FUNCTIONS IN: dipeptide transporter activity, tripeptide transporter activity, transporter activity; INVOLVED IN: dipeptide transport, oligopeptide transport, nitrogen compound metabolic process, tripeptide transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 40 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: PTR2 family proton/oligopeptide symporter, conserved site (InterPro:IPR018456), Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: peptide transporter 5 (TAIR:AT5G01180.1); Has 8339 Blast hits to 7886 proteins in 1502 species: Archae - 0; Bacteria - 4164; Metazoa - 798; Fungi - 498; Plants - 2234; Viruses - 0; Other Eukaryotes - 645 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    20045603..20048745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115274.3 → NP_190982.1  peptide transporter 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190982.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9M390
    UniProtKB/TrEMBL
    A0A178VD50, A0A5S9XKP7
    Conserved Domains (1) summary
    cd17418
    Location:28 → 561
    MFS_NPF8; NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters

  2. NM_001339651.1 → NP_001326764.1  peptide transporter 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9M390
    UniProtKB/TrEMBL
    A0A178VD50, A0A5S9XKP7
    Conserved Domains (1) summary
    cd17418
    Location:28 → 561
    MFS_NPF8; NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M390.1

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