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MDAR1 monodehydroascorbate reductase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824454, updated on 18-Sep-2024

Summary

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Official Symbol
MDAR1
Official Full Name
monodehydroascorbate reductase 1
Primary source
TAIR:AT3G52880
Locus tag
AT3G52880
See related
Araport:AT3G52880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMDAR1; monodehydroascorbate reductase 1
Summary
Encodes a peroxisomal monodehydroascorbate reductase, involved in the ascorbate-glutathione cycle which removes toxic H2O2
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Genomic context

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See MDAR1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (19601167..19604597, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene mediator of RNA polymerase II transcription subunit-like protein Neighboring gene ncRNA Neighboring gene IQ calmodulin-binding motif family protein Neighboring gene KCBP-interacting protein kinase Neighboring gene RAB6-interacting golgin (DUF662) Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses. Eltayeb AE, et al. Planta, 2007 Apr. PMID 17043889
  2. Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase. Lisenbee CS, et al. Plant J, 2005 Sep. PMID 16146528
  3. The plasmodesmal protein PDLP1 localises to haustoria-associated membranes during downy mildew infection and regulates callose deposition. Caillaud MC, et al. PLoS Pathog, 2014 Oct. PMID 25393742, Free PMC Article
  4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
  5. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When expressed in transgenic tobacco, confers enhanced tolerance against ozone, salt and polyethylene glycol stress.
    Title: Overexpression of monodehydroascorbate reductase in transgenic tobacco confers enhanced tolerance to ozone, salt and polyethylene glycol stresses.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001161202.1
NM_115148.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables monodehydroascorbate reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monodehydroascorbate reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hydrogen peroxide catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome HDA PubMed 

General protein information

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Preferred Names
monodehydroascorbate reductase 1
NP_001154674.1
  • monodehydroascorbate reductase 1 (MDAR1); CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: Pyridine nucleotide-disulphide oxidoreductase family protein (TAIR:AT5G03630.1); Has 30852 Blast hits to 30793 proteins in 3038 species: Archae - 685; Bacteria - 24210; Metazoa - 865; Fungi - 584; Plants - 707; Viruses - 0; Other Eukaryotes - 3801 (source: NCBI BLink).
NP_190856.1
  • monodehydroascorbate reductase 1 (MDAR1); FUNCTIONS IN: monodehydroascorbate reductase (NADH) activity; INVOLVED IN: response to cadmium ion, peptidyl-cysteine S-nitrosylation, hydrogen peroxide catabolic process; LOCATED IN: peroxisomal matrix, apoplast, chloroplast, peroxisome, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: Pyridine nucleotide-disulphide oxidoreductase family protein (TAIR:AT5G03630.1); Has 31553 Blast hits to 31492 proteins in 3048 species: Archae - 709; Bacteria - 24685; Metazoa - 865; Fungi - 647; Plants - 730; Viruses - 0; Other Eukaryotes - 3917 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    19601167..19604597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115148.4 → NP_190856.1  monodehydroascorbate reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190856.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WUV6, Q8LBV9, Q9LFA3
    UniProtKB/TrEMBL
    A0A178VLU2, A0A5S9XK85, A0A654FGJ8
    Conserved Domains (1) summary
    pfam07992
    Location:6 → 322
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  2. NM_001161202.1 → NP_001154674.1  monodehydroascorbate reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154674.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FGJ8, F4J849
    Conserved Domains (2) summary
    pfam07992
    Location:50 → 354
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    cl21454
    Location:205 → 279
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LFA3.1

Gene LinkOut

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