VSR1 vacuolar sorting receptor homolog 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: VSR1
Official Full Name: vacuolar sorting receptor homolog 1
Primary source: TAIR:AT3G52850
Locus tag: AT3G52850
See related: Araport:AT3G52850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA EPIDERMAL GROWTH FACTOR RECEPTOR-LIKE PROTEIN; ATELP; ATELP1; ATVSR1; binding protein of 80 kDa 1;1; BP-80; BP80; BP80-1;1; BP80B; GFS1; Green fluorescent seed 1; VACUOLAR SORTING RECEPTOR 1;1; vacuolar sorting receptor homolog 1; VSR-1; VSR1;1
Summary: Encodes the Vacuolar Sorting Receptor-1 (VSR-1)/Epidermal Growth Factor Receptor-like protein1(VSR-1/ATELP1). Binds vacuolar targeting signals. Involved in sorting seed storage proteins into vacuoles.
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Genomic context

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See VSR1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 12

Sequence:: Chromosome: 3; NC_003074.8 (19587756..19591947)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural insights into how vacuolar sorting receptors recognize the sorting determinants of seed storage proteins.
Title: Structural insights into how vacuolar sorting receptors recognize the sorting determinants of seed storage proteins.
VSR1 interacts with adaptor complex AP-4 at the trans-Golgi network and participates in the vacuolar protein sorting.
Title: The Adaptor Complex AP-4 Regulates Vacuolar Protein Sorting at the trans-Golgi Network by Interacting with VACUOLAR SORTING RECEPTOR1.
The crystal structures of the protease-associated domain of VSR isoform 1 from Arabidopsis thaliana (VSR1PA) alone and complexed with a cognate peptide containing the barley (Hordeum vulgare) aleurain, are reported.
Title: How vacuolar sorting receptor proteins interact with their cargo proteins: crystal structures of apo and cargo-bound forms of the protease-associated domain from an Arabidopsis vacuolar sorting receptor.
N-glycosylation of AtVSR1 plays a critical role in its function as a Vacuolar sorting receptor (VSR) in plants.
Title: N-linked glycosylation of AtVSR1 is important for vacuolar protein sorting in Arabidopsis.
required for osmotic stress-induced abscisic acid biosynthesis
Title: The Arabidopsis Vacuolar Sorting Receptor1 is required for osmotic stress-induced abscisic acid biosynthesis.
In mag1-1 mutants, VSR1 failed to recycle from the PVC to the TGN; rather, a significant proportion was transported to the LV; VSR1 overexpression rescued this defect
Title: Trafficking of vacuolar proteins: the crucial role of Arabidopsis vacuolar protein sorting 29 in recycling vacuolar sorting receptor.
VSR1, VSR3, and VSR4 exhibit functional redundancy in their role for the vacuolar trafficking of soluble proteins in vegetative cells.
Title: Functional identification of sorting receptors involved in trafficking of soluble lytic vacuolar proteins in vegetative cells of Arabidopsis.
findings show that that VSR1, VSR3 and VSR4 participate in vacuolar sorting of VAC2 in vegetative tissues, and 12S globulins and 2S albumins in seeds
Title: Functional specialization within the vacuolar sorting receptor family: VSR1, VSR3 and VSR4 sort vacuolar storage cargo in seeds and vegetative tissues.
These data suggest that homomeric interaction of AtVSR1 is critical for its function as a vacuolar sorting receptor.
Title: Homomeric interaction of AtVSR1 is essential for its function as a vacuolar sorting receptor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_115145.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables amino-terminal vacuolar sorting propeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vacuolar sorting signal binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to vacuole transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Golgi to vacuole transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within vacuolar transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
part_of Golgi transport complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in intracellular anatomical structure	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: vacuolar sorting receptor homolog 1

NP_190853.1

vacuolar sorting receptor homolog 1 (VSR1); FUNCTIONS IN: amino-terminal vacuolar sorting propeptide binding; INVOLVED IN: Golgi to vacuole transport, vacuolar transport, protein targeting to vacuole; LOCATED IN: trans-Golgi network, Golgi apparatus, plasma membrane, integral to plasma membrane, Golgi transport complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protease-associated PA (InterPro:IPR003137), EGF-like calcium-binding, conserved site (InterPro:IPR018097), EGF calcium-binding (InterPro:IPR013091), Growth factor, receptor (InterPro:IPR009030); BEST Arabidopsis thaliana protein match is: VACUOLAR SORTING RECEPTOR 2 (TAIR:AT2G30290.2); Has 12319 Blast hits to 5607 proteins in 222 species: Archae - 0; Bacteria - 78; Metazoa - 11101; Fungi - 9; Plants - 529; Viruses - 0; Other Eukaryotes - 602 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

19587756..19591947

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115145.2 → NP_190853.1 vacuolar sorting receptor homolog 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190853.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P93026, P94037, Q94AC0

UniProtKB/TrEMBL

A0A5S9XKI3, A0A654FGW5

Conserved Domains (2) summary

smart00179
Location:512 → 543

EGF_CA; Calcium-binding EGF-like domain

cl28883
Location:46 → 173

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...