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PHF1 phosphate transporter traffic facilitator1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824384, updated on 18-Sep-2024

Summary

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Official Symbol
PHF1
Official Full Name
phosphate transporter traffic facilitator1
Primary source
TAIR:AT3G52190
Locus tag
AT3G52190
See related
Araport:AT3G52190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtPHF1; phosphate transporter traffic facilitator1; T25B15.3
Summary
Encodes a plant specific protein structurally related to the SEC12 proteins of the early secretory pathway. Mutation of PHF1 impairs Pi transport. Expression was detected in all tissues, and was induced by Pi starvation. Localized in endoplasmic reticulum (ER), and mutation of PHF1 resulted in ER retention and reduced accumulation of the plasma membrane PHT1;1 transporter.
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Genomic context

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See PHF1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Sequence:
Chromosome: 3; NC_003074.8 (19353867..19357261, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene DNA binding protein Neighboring gene dual specificity protein phosphatase (DsPTP1) family protein Neighboring gene Dihydrolipoamide acetyltransferase, long form protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene leukocyte immunoglobulin-like receptor family A protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 is a plant-specific SEC12-related protein that enables the endoplasmic reticulum exit of a high-affinity phosphate transporter in Arabidopsis. González E, et al. Plant Cell, 2005 Dec. PMID 16284308, Free PMC Article
  2. Identification of downstream components of ubiquitin-conjugating enzyme PHOSPHATE2 by quantitative membrane proteomics in Arabidopsis roots. Huang TK, et al. Plant Cell, 2013 Oct. PMID 24122829, Free PMC Article
  3. A mutant of the Arabidopsis phosphate transporter PHT1;1 displays enhanced arsenic accumulation. Catarecha P, et al. Plant Cell, 2007 Mar. PMID 17400898, Free PMC Article
  4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
  5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_115079.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphate ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
phosphate transporter traffic facilitator1
NP_566961.1
  • phosphate transporter traffic facilitator1 (PHF1); FUNCTIONS IN: nucleotide binding; INVOLVED IN: cellular response to phosphate starvation, ER to Golgi vesicle-mediated transport, phosphate transport; LOCATED IN: endoplasmic reticulum, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat 2 (InterPro:IPR019782), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT5G50550.1); Has 6481 Blast hits to 4280 proteins in 402 species: Archae - 34; Bacteria - 2283; Metazoa - 1521; Fungi - 1505; Plants - 384; Viruses - 0; Other Eukaryotes - 754 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    19353867..19357261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_115079.4 → NP_566961.1  phosphate transporter traffic facilitator1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566961.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GYE0, Q9SUY6
    UniProtKB/TrEMBL
    A0A178V954, A0A384KIG4, Q0IGK5
    Conserved Domains (2) summary
    sd00039
    Location:127 → 162
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:127 → 318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GYE0.2

Gene LinkOut

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