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MDAR4 monodehydroascorbate reductase 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 822402, updated on 18-Sep-2024

Summary

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Official Symbol
MDAR4
Official Full Name
monodehydroascorbate reductase 4
Primary source
TAIR:AT3G27820
Locus tag
AT3G27820
See related
Araport:AT3G27820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMDAR4; monodehydroascorbate reductase 4; MONODEHYDROASCORBATE REDUCTASE 4
Summary
Encodes a peroxisome membrane-bound monodehydroascorbate reductase, involved in the ascorbate-glutathione cycle which removes toxic H2O2
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Genomic context

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See MDAR4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (10315010..10318154)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene myb domain protein 21 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene tRNA-Pro Neighboring gene ribosomal protein L12-A Neighboring gene Gamma-thionin family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MONODEHYROASCORBATE REDUCTASE4 is required for seed storage oil hydrolysis and postgerminative growth in Arabidopsis. Eastmond PJ. Plant Cell, 2007 Apr. PMID 17449810, Free PMC Article
  2. Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase. Lisenbee CS, et al. Plant J, 2005 Sep. PMID 16146528
  3. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MDAR4 component of the ascorbate-dependent electron transfer system is necessary to detoxify hydrogen peroxide which escapes from the peroxisome.
    Title: MONODEHYROASCORBATE REDUCTASE4 is required for seed storage oil hydrolysis and postgerminative growth in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_113698.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables monodehydroascorbate reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monodehydroascorbate reductase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hydrogen peroxide catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast envelope HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
monodehydroascorbate reductase 4
NP_189420.1
  • monodehydroascorbate reductase 4 (MDAR4); FUNCTIONS IN: monodehydroascorbate reductase (NADH) activity; INVOLVED IN: hydrogen peroxide catabolic process; LOCATED IN: peroxisomal membrane, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: monodehydroascorbate reductase 1 (TAIR:AT3G52880.1); Has 27219 Blast hits to 27159 proteins in 2894 species: Archae - 579; Bacteria - 21951; Metazoa - 737; Fungi - 533; Plants - 600; Viruses - 0; Other Eukaryotes - 2819 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    10315010..10318154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113698.4 → NP_189420.1  monodehydroascorbate reductase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_189420.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LK94
    UniProtKB/TrEMBL
    A0A178VES2, A0A5S9XHX6
    Conserved Domains (1) summary
    pfam07992
    Location:29 → 321
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LK94.1

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