LTA2 2-oxoacid dehydrogenases acyltransferase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LTA2
Official Full Name: 2-oxoacid dehydrogenases acyltransferase family protein
Primary source: TAIR:AT3G25860
Locus tag: AT3G25860
See related: Araport:AT3G25860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DIHYDROLIPOAMIDE S-ACETYLTRANSFERASE; PLASTID E2 SUBUNIT OF PYRUVATE DECARBOXYLASE; PLE2
Summary: Nuclear encoded dihydrolipoamide S-acetyltransferase (LTA2) that encodes teh Pyruvate Decarboxylase E2 subunit. Mutant has embryo defect.
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Genomic context

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See LTA2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 6

Sequence:: Chromosome: 3; NC_003074.8 (9460433..9463013)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The A. thaliana plastidial E2 subunit includes a single lipoyl-prosthetic group covalently attached to Lys96.
Title: Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_113489.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables dihydrolipoyllysine-residue acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast thylakoid	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
part_of pyruvate dehydrogenase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-oxoacid dehydrogenases acyltransferase family protein

NP_189215.1

LTA2; FUNCTIONS IN: dihydrolipoyllysine-residue acetyltransferase activity; INVOLVED IN: metabolic process, acetyl-CoA biosynthetic process from pyruvate; LOCATED IN: cytosolic ribosome, chloroplast stroma, chloroplast, membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: 2-oxo acid dehydrogenase, lipoyl-binding site (InterPro:IPR003016), E3 binding (InterPro:IPR004167), 2-oxoacid dehydrogenase acyltransferase, catalytic domain (InterPro:IPR001078), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: 2-oxoacid dehydrogenases acyltransferase family protein (TAIR:AT1G34430.1); Has 23844 Blast hits to 20819 proteins in 2344 species: Archae - 101; Bacteria - 13163; Metazoa - 1146; Fungi - 799; Plants - 467; Viruses - 32; Other Eukaryotes - 8136 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

9460433..9463013

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113489.3 → NP_189215.1 2-oxoacid dehydrogenases acyltransferase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189215.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LUA6, Q9SQI8

UniProtKB/TrEMBL

A0A178V5Z1, A0A5S9XFR8

Conserved Domains (1) summary

PRK11856
Location:55 → 480

PRK11856; branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed