BHLH32 basic helix-loop-helix 32 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BHLH32
Official Full Name: basic helix-loop-helix 32
Primary source: TAIR:AT3G25710
Locus tag: AT3G25710
See related: Araport:AT3G25710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATAIG1; basic helix-loop-helix 32; TARGET OF MONOPTEROS 5; TMO5
Summary: Encodes a basic helix#Aeiloop#Aeihelix transcription factor that is expressed in the hypophysis-adjacent embryo cells, and is required and partially sufficient for MP-dependent root initiation. Involved in response to phosphate starvation. Negative regulator of root hair development, anthocyanin formation and Pi content.
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Genomic context

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See BHLH32 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (9369499..9371487)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
Title: LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
Title: Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
Study revealed the evolutionary trajectory for the heterodimeric TMO5/LHW transcription factor complex, which is rate-limiting for vascular cell proliferation in Arabidopsis thaliana. Both regulators have origins predating vascular tissue emergence, and even terrestrialization. TMO5 evolved its modern function, including dimerization with LHW, at the origin of land plants.
Title: Evolution of vascular plants through redeployment of ancient developmental regulators.
TARGET OF MP, TMO5 and TMO7 encode basic helix-loop-helix (bHLH) transcription factors that are expressed in the hypophysis-adjacent embryo cells, and are required and partially sufficient for MONOPTEROS-dependent root initiation. [TMO5]
Title: MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_113470.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within root development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within root hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: basic helix-loop-helix 32

NP_189199.1

basic helix-loop-helix 32 (BHLH32); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G68810.1); Has 2800 Blast hits to 2795 proteins in 201 species: Archae - 0; Bacteria - 0; Metazoa - 397; Fungi - 30; Plants - 2368; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

9369499..9371487

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113470.3 → NP_189199.1 basic helix-loop-helix 32 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189199.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LS08

UniProtKB/TrEMBL

A0A178VA88, A0A5S9XFL3

Conserved Domains (2) summary

cd11455
Location:126 → 204

bHLH_AtAIG1_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins

cl09141
Location:218 → 306

ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme