U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LAG1 TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 822140, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
LAG1
Official Full Name
TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein
Primary source
TAIR:AT3G25540
Locus tag
AT3G25540
See related
Araport:AT3G25540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
LAG One Homologue 1; LAG1 HOMOLOG 1; LOH1; LONGEVITY ASSURANCE GENE 1
Summary
Encodes a ceramide synthase that together with LOH3 is essential for production of ceramides containing Very Long Chain Fatty acid VLCFA-Ceramides(mainly C 22 to 26).
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LAG1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (9274335..9276685)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5 Neighboring gene glyoxylate reductase 1 Neighboring gene trigger factor Neighboring gene F-box family protein Neighboring gene NSP-interacting kinase 2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis. Luttgeharm KD, et al. Biochem J, 2016 Mar 1. PMID 26635357
  2. Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance. Luttgeharm KD, et al. Plant Physiol, 2015 Oct. PMID 26276842, Free PMC Article
  3. Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana. Ternes P, et al. New Phytol, 2011 Dec. PMID 21883234
  4. Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis. Markham JE, et al. Plant Cell, 2011 Jun. PMID 21666002, Free PMC Article
  5. ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity. Kimberlin AN, et al. Plant Physiol, 2016 Oct. PMID 27506241, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings indicate that AtORM1 and AtORM2 mediation of serine palmitoyltransferase (SPT) activity differentially regulates functionally distinct ceramide synthase activities as part of a broader sphingolipid homeostatic regulatory network.
    Title: ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity.
  2. The role of At3g25540 in sphingolipid metabolism, mycotoxin resistance and cell death.
    Title: Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance.
  3. Spontaneous cell death in the loh1 line is triggered either by the accumulation of free trihydroxy sphingoid bases or ceramide species with C(16) fatty acid.[LOH1]
    Title: Disruption of the ceramide synthase LOH1 causes spontaneous cell death in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help
NM_001338755.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ceramide phosphoethanolamine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sphingosine N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine N-acyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endomembrane system organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of auxin polar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein
NP_001319643.1
  • LONGEVITY ASSURANCE GENE 1 (LAG1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: Golgi apparatus, endoplasmic reticulum, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Longevity assurance, LAG1/LAC1 (InterPro:IPR016439), TRAM/LAG1/CLN8 homology domain (InterPro:IPR006634); BEST Arabidopsis thaliana protein match is: LAG1 longevity assurance homolog 3 (TAIR:AT1G13580.3); Has 1255 Blast hits to 1255 proteins in 227 species: Archae - 0; Bacteria - 0; Metazoa - 591; Fungi - 304; Plants - 188; Viruses - 3; Other Eukaryotes - 169 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    9274335..9276685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001338756.1 → NP_001327930.1  TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LTU4

  2. NM_113450.5 → NP_566769.1  TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566769.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LDF2
    UniProtKB/TrEMBL
    A0A178VEQ4, A0A5S9XFN0
    Conserved Domains (1) summary
    smart00724
    Location:76 → 289
    TLC; TRAM, LAG1 and CLN8 homology domains

  3. NM_001338755.1 → NP_001319643.1  TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LDF2
    UniProtKB/TrEMBL
    A0A178VEQ4, A0A5S9XFN0
    Conserved Domains (1) summary
    smart00724
    Location:76 → 289
    TLC; TRAM, LAG1 and CLN8 homology domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LDF2.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools