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ROF1 rotamase FKBP 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 822117, updated on 18-Sep-2024

Summary

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Official Symbol
ROF1
Official Full Name
rotamase FKBP 1
Primary source
TAIR:AT3G25230
Locus tag
AT3G25230
See related
Araport:AT3G25230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATFKBP62; FK506 BINDING PROTEIN 62; FKBP62; rotamase FKBP 1
Summary
Encodes a a high molecular weight member of the FK506 binding protein (FKBP) family. It has three FKBP12-like domains, tetratricopeptide repeats, and a putative calmodulin binding domain. Modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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Genomic context

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See ROF1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Sequence:
Chromosome: 3; NC_003074.8 (9188096..9191630)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene sulfate/thiosulfate import ATP-binding protein, putative (DUF506) Neighboring gene AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis thaliana immunophilin ROF1 directly interacts with PI(3)P and PI(3,5)P2 and affects germination under osmotic stress. Karali D, et al. PLoS One, 2012. PMID 23133621, Free PMC Article
  2. Novel structure of a high molecular weight FK506 binding protein from Arabidopsis thaliana. Vucich VA, et al. Mol Gen Genet, 1996 Oct 16. PMID 8914512
  3. Involvement of Arabidopsis ROF2 (FKBP65) in thermotolerance. Meiri D, et al. Plant Mol Biol, 2010 Jan. PMID 19876748
  4. Dynamics of mRNA fate during light stress and recovery: from transcription to stability and translation. Smith AB, et al. Plant J, 2024 Feb. PMID 37947266, Free PMC Article
  5. Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1. Thirumalaikumar VP, et al. Autophagy, 2021 Sep. PMID 32967551, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1.
    Title: Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1.
  2. ROF1 plays an important role in the osmotic/salt stress responses of germinating Arabidopsis thaliana seedlings
    Title: The Arabidopsis thaliana immunophilin ROF1 directly interacts with PI(3)P and PI(3,5)P2 and affects germination under osmotic stress.
  3. ROF1 prolongs thermotolerance by sustaining the levels of small HSPs that are essential for survival at high temperatures.
    Title: Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001125223.1
NM_113429.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular heat acclimation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to high light intensity IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within seed germination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
rotamase FKBP 1
NP_001118695.1
  • rotamase FKBP 1 (ROF1); CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-type peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G48570.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_189160.3
  • rotamase FKBP 1 (ROF1); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, calmodulin binding; INVOLVED IN: response to cadmium ion, response to heat, response to wounding; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-type peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G48570.1); Has 23486 Blast hits to 15115 proteins in 1840 species: Archae - 212; Bacteria - 9362; Metazoa - 6200; Fungi - 1716; Plants - 1995; Viruses - 0; Other Eukaryotes - 4001 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    9188096..9191630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113429.5 → NP_189160.3  rotamase FKBP 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_189160.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38931, Q38949, Q9LSF3
    UniProtKB/TrEMBL
    A0A178VH19, A0A5S9XH24
    Conserved Domains (4) summary
    COG1047
    Location:174 → 234
    SlpA; FKBP-type peptidyl-prolyl cis-trans isomerase 2 [Posttranslational modification, protein turnover, chaperones]
    TIGR00990
    Location:357 → 537
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:400 → 438
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:50 → 142
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. NM_001125223.1 → NP_001118695.1  rotamase FKBP 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FAH8, B3H746
    Conserved Domains (4) summary
    sd00006
    Location:400 → 438
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:50 → 142
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam00515
    Location:483 → 516
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:443 → 514
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q38931.2

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