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PAC1 20S proteasome alpha subunit C1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821774, updated on 18-Sep-2024

Summary

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Official Symbol
PAC1
Official Full Name
20S proteasome alpha subunit C1
Primary source
TAIR:AT3G22110
Locus tag
AT3G22110
See related
Araport:AT3G22110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
20S proteasome alpha subunit C1; 20S PROTEASOME SUBUNIT PAC1
Summary
Encodes the alpha-3 subunit of 20s proteasome.
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Genomic context

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See PAC1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_003074.8 (7792549..7794262, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene ncRNA Neighboring gene cell wall-plasma membrane linker protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
  2. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
  3. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660
  4. Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes. Book AJ, et al. J Biol Chem, 2010 Aug 13. PMID 20516081, Free PMC Article
  5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_113108.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosolic ribosome HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex TAS
Traceable Author Statement
more info
 PubMed 
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
20S proteasome alpha subunit C1
NP_188850.1
  • 20S proteasome alpha subunit C1 (PAC1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: response to cadmium ion, ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein (TAIR:AT4G15165.1); Has 7432 Blast hits to 7428 proteins in 553 species: Archae - 896; Bacteria - 261; Metazoa - 2465; Fungi - 1789; Plants - 945; Viruses - 0; Other Eukaryotes - 1076 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7792549..7794262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113108.5 → NP_188850.1  20S proteasome alpha subunit C1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188850.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O23711, O81148
    UniProtKB/TrEMBL
    A0A178VJ65, A0A5S9XEH3, A0A5S9XSS7
    Conserved Domains (1) summary
    cd03752
    Location:3 → 215
    proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81148.1

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