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AHP1 histidine-containing phosphotransmitter 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821705, updated on 18-Sep-2024

Summary

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Official Symbol
AHP1
Official Full Name
histidine-containing phosphotransmitter 1
Primary source
TAIR:AT3G21510
Locus tag
AT3G21510
See related
Araport:AT3G21510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
histidine-containing phosphotransmitter 1
Summary
Encodes AHP1, one of the six Arabidopsis thaliana histidine phosphotransfer proteins (AHPs). AHPs function as redundant positive regulators of cytokinin signaling. Members of the AHP gene family include: AT3G21510 (AHP1), AT3G29350 (AHP2), AT5G39340 (AHP3), AT3G16360 (AHP4), AT1G03430 (AHP5) and AT1G80100 (AHP6).
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Genomic context

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See AHP1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (7577712..7579789, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene 1-deoxy-D-xylulose 5-phosphate synthase 1 Neighboring gene ncRNA Neighboring gene DNAse I-like superfamily protein Neighboring gene transmembrane protein, putative (DUF679 domain membrane protein 1)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation alters the interaction of the Arabidopsis phosphotransfer protein AHP1 with its sensor kinase ETR1. Scharein B, et al. PLoS One, 2011. PMID 21912672, Free PMC Article
  2. S-nitrosylation of phosphotransfer proteins represses cytokinin signaling. Feng J, et al. Nat Commun, 2013. PMID 23443557
  3. Arabidopsis histidine kinase CKI1 acts upstream of histidine phosphotransfer proteins to regulate female gametophyte development and vegetative growth. Deng Y, et al. Plant Cell, 2010 Apr. PMID 20363773, Free PMC Article
  4. Ethylene signaling: identification of a putative ETR1-AHP1 phosphorelay complex by fluorescence spectroscopy. Scharein B, et al. Anal Biochem, 2008 Jun 1. PMID 18384742
  5. The Arabidopsis eukaryotic translation initiation factor eIF5A-2 regulates root protoxylem development by modulating cytokinin signaling. Ren B, et al. Plant Cell, 2013 Oct. PMID 24163315, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutating selected interface residues of ARR4 either abolished or destabilized the interaction. D45A and Y96A mutations weakened interaction with AHP1, and exhibited weaker rescue of root elongation in the hextuple mutants.
    Title: Destabilization of interaction between cytokinin signaling intermediates AHP1 and ARR4 modulates Arabidopsis development.
  2. The first crystal structure of a plant histidine kinase receiver domain(RD), AHK5(RD), in complex with one of its cognate phosphotransfer proteins, AHP1.
    Title: Structure-function analysis of Arabidopsis thaliana histidine kinase AHK5 bound to its cognate phosphotransfer protein AHP1.
  3. A nitrosomimetic mutation of AHP1 causes reduced phosphorylation of AHP1 and ARR1, thereby resulting in a compromised cytokinin response.
    Title: S-nitrosylation of phosphotransfer proteins represses cytokinin signaling.
  4. interaction of ETR1 and AHP1
    Title: Phosphorylation alters the interaction of the Arabidopsis phosphotransfer protein AHP1 with its sensor kinase ETR1.
  5. Fluorescence polarization studies demonstrate a specific interaction of ETR1 with the histidine-containing transfer protein AHP1, supporting the idea that a phosphorelay module is involved in ethylene signaling
    Title: Ethylene signaling: identification of a putative ETR1-AHP1 phosphorelay complex by fluorescence spectroscopy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_113046.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histidine phosphotransfer kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histidine phosphotransfer kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cytokinin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytokinin-activated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within embryo sac development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within multidimensional cell growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphorelay signal transduction system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell division IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cytokinin-activated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histidine-containing phosphotransmitter 1
NP_188788.1
  • histidine-containing phosphotransmitter 1 (AHP1); CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, phosphotransfer (Hpt) domain (InterPro:IPR008207); BEST Arabidopsis thaliana protein match is: histidine-containing phosphotransfer factor 5 (TAIR:AT1G03430.1); Has 358 Blast hits to 357 proteins in 69 species: Archae - 2; Bacteria - 42; Metazoa - 0; Fungi - 41; Plants - 268; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7577712..7579789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113046.4 → NP_188788.1  histidine-containing phosphotransmitter 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188788.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZNV9
    UniProtKB/TrEMBL
    A0A178V856, A0A5S9XFV9
    Conserved Domains (1) summary
    pfam01627
    Location:44 → 128
    Hpt; Hpt domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZNV9.1

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