TOM40 translocase of the outer mitochondrial membrane 40 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TOM40
Official Full Name: translocase of the outer mitochondrial membrane 40
Primary source: TAIR:AT3G20000
Locus tag: AT3G20000
See related: Araport:AT3G20000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: translocase of the outer mitochondrial membrane 40
Summary: Encodes a component of the TOM receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. With TOM22, functions as the transit peptide receptor at the surface of the mitochondrial outer membrane and facilitates the movement of preproteins into the translocation pore.
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Genomic context

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See TOM40 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 11

Sequence:: Chromosome: 3; NC_003074.8 (6967462..6970652)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtMic60 contributes to the export of phosphatidylethanolamine from mitochondria and the import of galactoglycerolipids from plastids during phosphate starvation. Furthermore, AtMic60 promotes lipid desorption from membranes, likely as an initial step for lipid transfer, and binds to Tom40, suggesting that AtMic60 could regulate the tethering between the inner and outer membranes of mitochondria.
Title: AtMic60 Is Involved in Plant Mitochondria Lipid Trafficking and Is Part of a Large Complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112890.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein-transporting ATPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to phosphate starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein targeting to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of MICOS complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plant-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: translocase of the outer mitochondrial membrane 40

NP_188634.1

translocase of the outer mitochondrial membrane 40 (TOM40); FUNCTIONS IN: voltage-gated anion channel activity, P-P-bond-hydrolysis-driven protein transmembrane transporter activity; INVOLVED IN: protein targeting to mitochondrion, anion transport; LOCATED IN: mitochondrial outer membrane, mitochondrion, mitochondrial inner membrane, plasma membrane, mitochondrial outer membrane translocase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: Eukaryotic porin family protein (TAIR:AT1G50400.1); Has 530 Blast hits to 530 proteins in 190 species: Archae - 0; Bacteria - 0; Metazoa - 257; Fungi - 140; Plants - 72; Viruses - 0; Other Eukaryotes - 61 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

6967462..6970652

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001338439.1 → NP_001326561.1 translocase of the outer mitochondrial membrane 40 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LPN4

Conserved Domains (1) summary

cd07305
Location:19 → 238

Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
NM_112890.5 → NP_188634.1 translocase of the outer mitochondrial membrane 40 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188634.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LHE5

UniProtKB/TrEMBL

A0A178V9B1, A0A5S9XED7

Conserved Domains (1) summary

cd07305
Location:28 → 309

Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)