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ARC5 P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821509, updated on 18-Sep-2024

Summary

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Official Symbol
ARC5
Official Full Name
P-loop containing nucleoside triphosphate hydrolases superfamily protein
Primary source
TAIR:AT3G19720
Locus tag
AT3G19720
See related
Araport:AT3G19720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ACCUMULATION AND REPLICATION OF CHLOROPLAST 5; DRP5B; Dynamin related protein 5B
Summary
Encodes a novel chloroplast division protein. Mutants of exhibit defects in chloroplast constriction, have enlarged, dumbbell-shaped chloroplasts. The ARC5 gene product shares similarity with the dynamin family of GTPases, which mediate endocytosis, mitochondrial division, and other organellar fission and fusion events in eukaryotes. Phylogenetic analysis showed that ARC5 is related to a group of dynamin-like proteins unique to plants. A GFP-ARC5 fusion protein localizes to a ring at the chloroplast division site. Chloroplast import and protease protection assays indicate that the ARC5 ring is positioned on the outer surface of the chloroplast. Facilitates separation of the two daughter chloroplasts.
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Genomic context

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See ARC5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
18
Sequence:
Chromosome: 3; NC_003074.8 (6850358..6855590, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene branched-chain aminotransferase4 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene eukaryotic initiation factor 4A-III

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery. Gao H, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12642673, Free PMC Article
  2. The Arabidopsis arc5 and arc6 mutations differentially affect plastid morphology in pavement and guard cells in the leaf epidermis. Fujiwara MT, et al. PLoS One, 2018. PMID 29466386, Free PMC Article
  3. PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring. Sun B, et al. Plant Physiol, 2020 Apr. PMID 32005784, Free PMC Article
  4. Plastid division control: the PDV proteins regulate DRP5B dynamin activity. Holtsmark I, et al. Plant Mol Biol, 2013 Jun. PMID 23595201
  5. Differential roles of Arabidopsis dynamin-related proteins DRP3A, DRP3B, and DRP5B in organelle division. Aung K, et al. J Integr Plant Biol, 2012 Nov. PMID 23046048

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.
    Title: PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.
  2. results support the notion that ARC5 is dispensable in the process of equal division of epidermal plastids, and indicate that dysfunctions in ARC5 and ARC6 differentially affect plastid replication among mesophyll cells, PCs, and GCs within a single leaf
    Title: The Arabidopsis arc5 and arc6 mutations differentially affect plastid morphology in pavement and guard cells in the leaf epidermis.
  3. The roles of DRP3A, DRP3B, and DRP5B in organelle division and plant development, were investigated.
    Title: Differential roles of Arabidopsis dynamin-related proteins DRP3A, DRP3B, and DRP5B in organelle division.
  4. Data indicate that that PDV1 and PDV2 inhibits DRP5B-mediated GTP hydrolysis in a ratio dependent manner.
    Title: Plastid division control: the PDV proteins regulate DRP5B dynamin activity.
  5. arc5 plastids appeared wild-type in the majority of nongreen tissues examined
    Title: Effects of arc3, arc5 and arc6 mutations on plastid morphology and stromule formation in green and nongreen tissues of Arabidopsis thaliana.
  6. ARC5, which encodes a cytosolic dynamin-like protein that is part of the chloroplast division machinery and arc mutants have large but fewer chloroplasts which have an effect on both the composition and structure of the photosynthetic apparatus. [ARC5]
    Title: Photosynthesis in Arabidopsis thaliana mutants with reduced chloroplast number.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001203006.1
NM_112862.4
NM_180284.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chloroplast fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chloroplast fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within peroxisome fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to gibberellin IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
P-loop containing nucleoside triphosphate hydrolases superfamily protein
NP_001189935.1
  • ACCUMULATION AND REPLICATION OF CHLOROPLAST 5 (ARC5); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: chloroplast fission, peroxisome fission; LOCATED IN: chloroplast outer membrane, peroxisome, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin, GTPase domain (InterPro:IPR001401); BEST Arabidopsis thaliana protein match is: Dynamin related protein 5A (TAIR:AT1G53140.1).
NP_188606.2
  • ACCUMULATION AND REPLICATION OF CHLOROPLAST 5 (ARC5); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: chloroplast fission, peroxisome fission; LOCATED IN: chloroplast outer membrane, peroxisome, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin, GTPase domain (InterPro:IPR001401); BEST Arabidopsis thaliana protein match is: Dynamin related protein 5A (TAIR:AT1G53140.1); Has 2186 Blast hits to 2177 proteins in 279 species: Archae - 0; Bacteria - 10; Metazoa - 945; Fungi - 507; Plants - 452; Viruses - 0; Other Eukaryotes - 272 (source: NCBI BLink).
NP_850615.2
  • ACCUMULATION AND REPLICATION OF CHLOROPLAST 5 (ARC5); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: chloroplast fission, peroxisome fission; LOCATED IN: chloroplast outer membrane, peroxisome, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin, GTPase domain (InterPro:IPR001401); BEST Arabidopsis thaliana protein match is: Dynamin related protein 5A (TAIR:AT1G53140.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6850358..6855590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180284.3 → NP_850615.2  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850615.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XDR2, A0A654F8U6, A0A7G2EM07
    Conserved Domains (1) summary
    cd08771
    Location:49 → 343
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  2. NM_112862.4 → NP_188606.2  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188606.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3EB39, Q84N64, Q9LJM3
    UniProtKB/TrEMBL
    A0A178VCF9, A0A7G2EM07
    Conserved Domains (1) summary
    cd08771
    Location:49 → 343
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

  3. NM_001203006.1 → NP_001189935.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189935.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2EM07, F4JCC8
    Conserved Domains (1) summary
    cd08771
    Location:49 → 343
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84N64.2

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